Y6461_DICDI
ID Y6461_DICDI Reviewed; 798 AA.
AC Q86HW6; Q551K8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Probable serine/threonine-protein kinase DDB_G0276461;
DE EC=2.7.11.1;
GN ORFNames=DDB_G0276461;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AAFI02000015; EAL69184.1; -; Genomic_DNA.
DR RefSeq; XP_643126.1; XM_638034.1.
DR AlphaFoldDB; Q86HW6; -.
DR SMR; Q86HW6; -.
DR STRING; 44689.DDB0229347; -.
DR PaxDb; Q86HW6; -.
DR EnsemblProtists; EAL69184; EAL69184; DDB_G0276461.
DR GeneID; 8620531; -.
DR KEGG; ddi:DDB_G0276461; -.
DR dictyBase; DDB_G0276461; -.
DR eggNOG; KOG1989; Eukaryota.
DR HOGENOM; CLU_352497_0_0_1; -.
DR InParanoid; Q86HW6; -.
DR OMA; EYENETN; -.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q86HW6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..798
FT /note="Probable serine/threonine-protein kinase
FT DDB_G0276461"
FT /id="PRO_0000362059"
FT DOMAIN 54..324
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 330..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 60..68
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 82
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 798 AA; 88840 MW; 39A551539F6F9CF0 CRC64;
MNRFLEFSNN FLEVAGNTIN NISSKSITDN VGNVWGNITG GRVGQVYDIN GRRVTEVKLV
AEGGFGFVYL VRDDYNNMYA LKRMFIQERE RLEAMKNEID VMQKLRNNPN IVKLEGFKIN
ENRNTRETEV LMLMEYCSGG SVLDIMNARG EFTRLEEREI LAIFSDVCNG VLAMHQQQPP
IAHRDLKIEN VLYCEHSNRY KLCDFGSSTI KTFNTATERG KAEDDINMFT TLFYRAPEMV
DLYRGQIIDE KVDVWALGCL LFKMAFYVDP FDGGSLQIIN NNYKIPDNSK YSNNFHKLIQ
FILVADPTQR PSINDLLNYL NEIRGSSRRG LQTFSSNNNN SNNNSNNNSN NNSNNNSVNN
SSNSINRPIR TSSSSNSTPN FNSPNTNNNN YNNNNNNSKN YGNTPNSTPP NAKKNIFDIL
GDDTTSSTSN SNNSPSVSRN NINNNSNNFN NNNNNNNNNN NNNNNNNNNN NNNNTNNNNS
NNNNYNNNNN KFDEFESWGN TPLQHPSPSN SNSNVIINNT NSSGKNNQNK SNSGNGNFFD
NDFEFEGFVS PTTNGSTNFE VNTTNTNVSL NSSTHSSSSF NNSSNNNNTN NSSVSVGSSI
NNSGTRLMNN SSGSLPQSRQ SSFNSTPQQQ QQQFNSSTNS GSYNNLTSSF NNLNISTSSS
ASISSSGGVS NNSDNSWNVT LTPSQSNKNS TGNLKPLNNN NNNNNNNNNR FANNTNSSRD
YSFDFSSPNT SNNNDFGSFV QPSSSSSLNT THFSKPNYNV NLNQTTSMTN NYNNNNYNNN
NNSNNNNNNS KVFDFGIL
