ID   Y651_METJA              Reviewed;         311 AA.
AC   Q58067;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Putative protease MJ0651;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=MJ0651;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the peptidase S49 family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98642.1; -; Genomic_DNA.
DR   RefSeq; WP_010870156.1; NC_000909.1.
DR   AlphaFoldDB; Q58067; -.
DR   SMR; Q58067; -.
DR   STRING; 243232.MJ_0651; -.
DR   EnsemblBacteria; AAB98642; AAB98642; MJ_0651.
DR   GeneID; 1451517; -.
DR   KEGG; mja:MJ_0651; -.
DR   eggNOG; arCOG01311; Archaea.
DR   HOGENOM; CLU_046540_0_0_2; -.
DR   InParanoid; Q58067; -.
DR   OMA; YVYDEIR; -.
DR   OrthoDB; 36138at2157; -.
DR   PhylomeDB; Q58067; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07023; S49_Sppa_N_C; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR004635; Pept_S49_SppA.
DR   InterPro; IPR002142; Peptidase_S49.
DR   Pfam; PF01343; Peptidase_S49; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR00706; SppA_dom; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome; Serine protease.
FT   CHAIN           1..311
FT                   /note="Putative protease MJ0651"
FT                   /id="PRO_0000171456"
FT   ACT_SITE        128
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        180
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   311 AA;  34665 MW;  C46AAC8451216D64 CRC64;
     MKKIYIILLI LFVILISLIG ASILLVMSLS GENVDLFGGE KIAKVYLCNE IYFDYNQGDG
     IFPQQKKDAR YYINLLDDLE KDDSVKGVLL VVNSPGGEVI ASEKLARKVE ELAKKKPVVV
     YVEGLDASGA YMVSAPADYI VAEKHSIVGS IGVRMDLMHY YGLMKKLGIN VTTIKAGKYK
     DIGSPFRPMT KEEKEYLQKM INETYMDFVK WVAEHRHLSI NYTLKIADGK IYSGEDAKKV
     GLVDEVGTEE DALKKLEQLA NVSNPEIVEY GLEENKGLFG LTYYLGYGIG KGIGEVLYGM
     EKINGRVELL S