ID   Y663_METJA              Reviewed;         494 AA.
AC   Q58077;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Uncharacterized protein MJ0663;
GN   OrderedLocusNames=MJ0663;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB98655.1; -; Genomic_DNA.
DR   PIR; G64382; G64382.
DR   AlphaFoldDB; Q58077; -.
DR   SMR; Q58077; -.
DR   STRING; 243232.MJ_0663; -.
DR   EnsemblBacteria; AAB98655; AAB98655; MJ_0663.
DR   KEGG; mja:MJ_0663; -.
DR   eggNOG; arCOG02000; Archaea.
DR   HOGENOM; CLU_013748_3_1_2; -.
DR   InParanoid; Q58077; -.
DR   OMA; IGVKFGC; -.
DR   PhylomeDB; Q58077; -.
DR   BioCyc; MetaCyc:MON-14614; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005948; C:acetolactate synthase complex; IBA:GO_Central.
DR   GO; GO:0003984; F:acetolactate synthase activity; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0009099; P:valine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   PANTHER; PTHR18968; PTHR18968; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..494
FT                   /note="Uncharacterized protein MJ0663"
FT                   /id="PRO_0000090834"
SQ   SEQUENCE   494 AA;  55355 MW;  1C62956C33D09D82 CRC64;
     MGGNIKFLEA MVDFLERNVK TIFSYPGEQI LPLYNEIEGS SIKNIMVRDE RGAGFMADGY
     ARITNYIGVC LATAGPGATN LTTPIATAYK DNSSVLAITG RCQRKYIGKN YFQEVNMDFL
     NFYKGYFVDK AEVSYIAKAF ADCLFNKKPV QLNIPVDLYK EEAKDINITT YTDIYKDDET
     PSNNIKEIDV KKPLFLIGQG IFGTLSYKEI VKISKILEKI NCPIATTFPA RGVINEKLEN
     CIGLVGRRGD LKSLLEADKI INIGSSLSYN TYVESVREKL LSKTENIQLK PKSIKELKEF
     FENLDVKNSS WIYKNSNKFQ PSGDYSNKIY EIIKNIPEDA IIVTDAGKHT VFTCLLKTCV
     IPRNIISSHS FGTMGFGLPA SIGVKFGTID FNIDREVVLI SGDGGFLMNV EELQVVAENN
     LKILMVVMKN NSLAEFCKIK NPNFNKIADA FEIDNCYIEN VDEIGSEIKG YLKKNKPLLV
     VVETENEPLP KPNI