ID   Y663_METTH              Reviewed;         412 AA.
AC   O26759;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Putative ammonium transporter MTH_663;
GN   OrderedLocusNames=MTH_663;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85168.1; -; Genomic_DNA.
DR   PIR; C69188; C69188.
DR   AlphaFoldDB; O26759; -.
DR   SMR; O26759; -.
DR   STRING; 187420.MTH_663; -.
DR   EnsemblBacteria; AAB85168; AAB85168; MTH_663.
DR   KEGG; mth:MTH_663; -.
DR   PATRIC; fig|187420.15.peg.644; -.
DR   HOGENOM; CLU_000445_33_0_2; -.
DR   OMA; MACWNSN; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   PANTHER; PTHR43029; PTHR43029; 1.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   TIGRFAMs; TIGR00836; amt; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..412
FT                   /note="Putative ammonium transporter MTH_663"
FT                   /id="PRO_0000139767"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   412 AA;  43138 MW;  1883F6503A2B776B CRC64;
     MEMTLMDAVL NSGDTAWMLV STALVMLMTV PGVALFYGGL TKKENVLNTM FLSLIAFAVT
     SIIWVLYGYQ FAFGADIMGF IGSPVNLLMN GVGVNTAAAL APTIPDFLYI AFQLTFAAIT
     VALISGAVVE RMKFSAWLAF IVLWVSLVYV PVAHWVWGGG FLAQLGALDF AGGTVVHINS
     GVAALALVYL LGKRKDTRLL PHNLGYSVIG ASLLWFGWFG FNAGSALTAG GLAASAFLVT
     NTAAAAGMVS WVIMDYLKVG KPTVLGGISG AVAGLVAITP AAGFVTVPAA LIIGLVTSVI
     SYLAVSYLKP RLGYDDALDV FGIHGMSGIW GSVATGLFAA PFINELGTGL IYGNPGQLTA
     QVIAVAVVAA YSFVVTLIIG KLLDFTVGLR VSGKEEMEGL DTHLHEETGY RI