ID   CASP1_STRAF             Reviewed;         189 AA.
AC   Q1W3A5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Casparian strip membrane protein 1;
DE            Short=SaCASP1;
DE   Flags: Fragment;
OS   Striga asiatica (Asiatic witchweed) (Buchnera asiatica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Orobanchaceae; Buchnereae; Striga.
OX   NCBI_TaxID=4170;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Liang L., Lynn D.G.;
RT   "Cloning of genes for Striga asiatica haustorium formation by suppressive
RT   subtractive hybridization (SSH).";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24920445; DOI=10.1104/pp.114.239137;
RA   Roppolo D., Boeckmann B., Pfister A., Boutet E., Rubio M.C.,
RA   Denervaud-Tendon V., Vermeer J.E., Gheyselinck J., Xenarios I., Geldner N.;
RT   "Functional and evolutionary analysis of the CASPARIAN STRIP MEMBRANE
RT   DOMAIN PROTEIN family.";
RL   Plant Physiol. 165:1709-1722(2014).
CC   -!- FUNCTION: Regulates membrane-cell wall junctions and localized cell
CC       wall deposition. Required for establishment of the Casparian strip
CC       membrane domain (CSD) and the subsequent formation of Casparian strips,
CC       a cell wall modification of the root endodermis that determines an
CC       apoplastic barrier between the intraorganismal apoplasm and the
CC       extraorganismal apoplasm and prevents lateral diffusion (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=Very restricted localization following a
CC       belt shape within the plasma membrane which coincides with the position
CC       of the Casparian strip membrane domain in the root endodermis.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Casparian strip membrane proteins (CASP)
CC       family. {ECO:0000305}.
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DR   EMBL; DQ442388; ABD98039.1; -; mRNA.
DR   AlphaFoldDB; Q1W3A5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   InterPro; IPR006459; CASP/CASPL.
DR   InterPro; IPR006702; CASP_dom.
DR   Pfam; PF04535; DUF588; 1.
DR   TIGRFAMs; TIGR01569; A_tha_TIGR01569; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell wall biogenesis/degradation; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..>189
FT                   /note="Casparian strip membrane protein 1"
FT                   /id="PRO_0000370730"
FT   TOPO_DOM        1..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..90
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   NON_TER         189
SQ   SEQUENCE   189 AA;  19990 MW;  F0205A44CD3A53E2 CRC64;
     MEKNESSAIE IAESSKERKG KAPLLAAAVG HDRAAGYKRG VSIFDLILRI SAATAALAAT
     IVMGTTEQTL PFFTQFFQFR AQYDDLPTFT FFVVGMAIVT GYLILSVPLS IVCIARPVAI
     GPRFLLIVCD TVTAVLATSA AGSSAAIVYL AHNGNSDANW LAICQQFNDF CQRVSGAVVA
     AFVAVVCSS