ID   Y6688_CANAL             Reviewed;         326 AA.
AC   Q59R32; A0A1D8PRC6; Q3MP01;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Virulence factor CaO19.6688;
GN   OrderedLocusNames=CAALFM_C703560WA; ORFNames=CaO19.13980, CaO19.6688;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   INDUCTION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=24610660; DOI=10.1128/ec.00051-14;
RA   Wilson D., Mayer F.L., Miramon P., Slesiona S., Jacobsen I.D., Hube B.;
RT   "Candida albicans specific genes: distinct roles in host-pathogen
RT   interactions.";
RL   Eukaryot. Cell 13:977-989(2014).
RN   [5]
RP   INDUCTION.
RX   PubMed=15273122; DOI=10.1128/aac.48.8.3064-3079.2004;
RA   Karababa M., Coste A.T., Rognon B., Bille J., Sanglard D.;
RT   "Comparison of gene expression profiles of Candida albicans azole-resistant
RT   clinical isolates and laboratory strains exposed to drugs inducing
RT   multidrug transporters.";
RL   Antimicrob. Agents Chemother. 48:3064-3079(2004).
CC   -!- FUNCTION: Virulence factor involved in pathogen-host interaction.
CC       Modulates host pro-inflammatory cytokine interleukin-1 beta (IL1B)
CC       expression. {ECO:0000269|PubMed:24610660}.
CC   -!- INDUCTION: Expression is induced during infection and decreased by
CC       benomyl treatment. {ECO:0000269|PubMed:15273122,
CC       ECO:0000269|PubMed:24610660}.
CC   -!- DISRUPTION PHENOTYPE: Leads to strong defects in host cell damage in a
CC       model of human oral epithelial cells. Exhibits reduced survival
CC       following co-incubation with a human macrophage cell line and causes
CC       more severe kidney pathology following intravenous murine infection.
CC       Leads also to higher levels of interleukin-1 beta (IL1B), following
CC       incubation with murine macrophages. {ECO:0000269|PubMed:24610660}.
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DR   EMBL; CP017629; AOW30698.1; -; Genomic_DNA.
DR   RefSeq; XP_712141.1; XM_707048.1.
DR   AlphaFoldDB; Q59R32; -.
DR   GeneID; 3646236; -.
DR   KEGG; cal:CAALFM_C703560WA; -.
DR   CGD; CAL0000191640; orf19.13980.
DR   VEuPathDB; FungiDB:C7_03560W_A; -.
DR   HOGENOM; CLU_882766_0_0_1; -.
DR   OrthoDB; 1756087at2759; -.
DR   PHI-base; PHI:4656; -.
DR   Proteomes; UP000000559; Chromosome 7.
PE   2: Evidence at transcript level;
KW   Reference proteome; Virulence.
FT   CHAIN           1..326
FT                   /note="Virulence factor CaO19.6688"
FT                   /id="PRO_0000429118"
FT   REGION          19..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..301
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  35964 MW;  498F2751178B1F73 CRC64;
     MSILINNGND YQLNSSETFN SLKSSPSSTS SLSSISTSSS SSCHKRSKAV DLNRNTSNSQ
     NSSISTAPTT ATAANTTPRK TSITIPSKLP SSWIPLRNGN IDYSRYYNTN QEEDNQEQQL
     QDGEPLSAPT TNNGTTKTAT ANANIIQDSF ETIPCFSSTT NTTITSSRSN PTNSTPTSND
     PSFPKQMINW NQFLQEEKDM NDNSSTINDD DKTFYMEQLN LNVGQTPNNN NNNNHGVSET
     ENDLLPGTSK SLIAKYHYQL NYGDENENET NDVREYEYGG GESRKRKSST TSDDRRPRRG
     GGGGGSRTSQ VFRNTLNKFT FKPKIK