Y6689_DICDI
ID Y6689_DICDI Reviewed; 2772 AA.
AC Q551A3; Q551A2;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Protein DDB_G0276689;
GN ORFNames=DDB_G0276689;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=16507593; DOI=10.1242/jcs.02819;
RA Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA Calvo R.M., Escalante R.;
RT "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT required for mitochondrial function and development.";
RL J. Cell Sci. 119:1154-1164(2006).
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:16507593}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL69102.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL69103.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000018; EAL69102.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000018; EAL69103.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_643035.1; XM_637943.1.
DR RefSeq; XP_643036.1; XM_637944.1.
DR SMR; Q551A3; -.
DR STRING; 44689.DDB0232152; -.
DR PaxDb; Q551A3; -.
DR EnsemblProtists; EAL69102; EAL69102; DDB_G0276689.
DR EnsemblProtists; EAL69103; EAL69103; DDB_G0276691.
DR GeneID; 8620640; -.
DR GeneID; 8620641; -.
DR KEGG; ddi:DDB_G0276689; -.
DR KEGG; ddi:DDB_G0276691; -.
DR dictyBase; DDB_G0276689; -.
DR eggNOG; KOG1811; Eukaryota.
DR InParanoid; Q551A3; -.
DR PRO; PR:Q551A3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR InterPro; IPR028730; ZFYVE26.
DR PANTHER; PTHR46591; PTHR46591; 2.
PE 4: Predicted;
KW Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..2772
FT /note="Protein DDB_G0276689"
FT /id="PRO_0000390619"
FT REPEAT 1065..1089
FT /note="LRR 1"
FT REPEAT 1393..1416
FT /note="LRR 2"
FT REPEAT 1543..1567
FT /note="LRR 3"
FT REPEAT 1899..1922
FT /note="LRR 4"
FT REPEAT 2414..2439
FT /note="LRR 5"
FT REGION 50..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1587..1622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1999..2021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2054..2083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2367..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2772 AA; 319388 MW; 4AD96133F47986BD CRC64;
MKLSESTINK DYPFLSEEED SKIISLICNY LSLGQFELAR ALILQSQEKQ QLKNQQKQTQ
SDNNNNNNNN NNNNNNNNNN NNCDRISSIL YHTIRNGPPS TWLTSESIPS SPHLSWLCSI
EFYQLNKDGF ISSISEKTLL LVEFAILIYT LLGEQQNNDS RNIQPIIQEL REYHYVLLSQ
QRQQSNNKNN NNNNIDNLSE QQIYQMESIL LRSKLGNSTI SILKTILINN TEFGRYIIKQ
FTNPFISSLN NNNNNNGISN SLLYSRYPVT QQLESLVAEV ITLLIDSSQY NEAYNLLSII
DISNNDNSNS NNNNNNNNNN INSDEVDSNS GDNNIISKLL ERVANLNNSN FGNNVEELTL
LKIPFSSKLS NLETDNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNGKSISRLK
IYESLLSNPT LTPLKTYLKH EESILKENSS QQQPIDFPEC FEILKNYFSL KPKQLDINSK
NNNNDNNNNN NNNSSSSGSN SSSSRNKNNL KNNLKSFDRK DSEYQNAESI FWYWYYHFLR
VNDRHYLEYA LEKSIDLIKN KRFEEALIVV KPFEKLLPLL ILLCWDHFEN DITSRKHLTN
LLDLSKGISK FNKNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNE WSCRRMIAVP
NSPNGHSLII GESTFDLLDE KSKTLRGSFS PSSMSPSIPP SASNDSSLTS SPYLLSLGRS
MTTNISNAIL SQLFHHSFIY VVKDCLPFIT SNDILKFIEK DPDFPINYQQ QQEQQEQQQQ
SNDSENLLSQ IALDKLNDMN LVRGYYLIKN ILKFFQYRAT STDAIVDKVE FDSVLDDVFD
LFKGISNANI SIGLIESLYL SLFLSNQDLK SNNNNTNDLG EISSSSSAFR LNNDFNYNNN
SNNNDKPNNN EFYQYYKKVI SNSSEENNLS YYLVNNNSHN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN SNNEINEQII EIIDNEFSYQ KLSKSQHKQY YITCVMLESL
INKLITLIDF IVDSSLQQQQ KQEIKKERIQ ILLLNLENLK HRVDLSKWIL NLDDNNYNHI
PFMSLVLMPI KSLILMAMRT NYPNFQIIIK YFDIPKDIEN QAYQFKSIPD LLDVLENNGG
GDNDDDGADI NLNQLTTSFN GINNDNIFQI LSDIVIGSNC NNSLIKKILK INNNNNNDND
NNNKSKSYLN WISILHKEYI DQISTTNSNS LYDILINPQS IPDKDYQNIS KMKQYINNKK
IIIKSLNRLI KCYDNTINNK NNNNNIDNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NIEDDVKIII ENDNNISNNQ ILSTLFKYIL SVNQIYSNCS DYSSIFRNIN QSPKSILQDI
VFNEKDYKKA EQLSNLLQVD LSDLIISSIS HTTPKNPPSS LFKSSTPESS VLNSPIFYIN
NQQQQQQQLQ LQQQQQQQQL QQQQQQQQQL QLQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
QQQQQLTNDN IQKNYLTMDL VNYFDKSSKL LSSLVCMLKS PDHKDVEPFI QFSIENSKKL
PSNSFSNWIN EILKAHTFYH KYFNQQQNNN YNNNNYNNNY NNNNNNNNNN NNNNNNNNNI
DNQQTINETF DYKLIQNSES IHQQQNFFFK IIQFFVNNNN LMDALKIADE YLEEGAPDWL
LKLLVFKDRS QGYKYIRRMR DKPKALNLVL ELYNNWDIAT CIDMIVICKS FLGLPDQINQ
QQQPTTTTTT TIQDQQDENI KNELNHLHKA FLLYQSILNN ANNGNVYRNW QEIKEICQND
PATMVRNLLD SKHYDLARKI RDHFSVSGIK KEIEERYLYY LLVEKDDASL ALQTLSELGE
ESISILDSLL PVINEISVKL FLVQFLLSNM RSKLSKEKLE ELTKQEIGYQ VLLVLPTDLQ
VEYSQFINHP LLIIEMLIMN EKIPLVAKLL LDIKELKDVD DLLTYYARKA LSFSRYLAKN
DLMMLDDYLQ KEFNDQDDYV SNNNYNKNDQ INSKEKDKDK KRKSFLSNLP IITNKSSQTI
KQSPSFEVED FRHEISNRSS TPPPPPPTET PSLNIVHSTS PNSSVSLLKD KNIQQKWLLT
GNDTVQDEKI RHSHFFIRSP SISLAKSLFD LCESKKKVYN TCIELYSNLS MLLSSNYSDD
NLLIINLIQQ LLMYTKLQLL RDPKSGGPTL VAVCDTYLGK VELFQSLVVS KCSGSMSLVD
LSDPQKARQL RDRLIQEDRL RLAIDVATKC NIPADSAWVS WGISLIQTGS YSEAREKFKY
CLTPTGPDRR VMSPSNSLSI DTIDSGVILN QIIQLLESPP SPNHSNFRSL YNYLLSTQGG
GSSSNLKSTP KIDDSMFYNL LQPQLLNNSS NNSNNNNNTN NNNNNNNAIT NLFSNAFSDK
KSLTNNNSSS INNTTIINNI EMDKNRLDEA IYYLKKYGNG RMLVNFLIKH NLYELACKTI
LSDSLSFNIF YDEIVLKAIA NSSLQDLFNT IKSIDPKLLA FQDHLLASCK NMNERKQYQL
LFEFQLYMGD NVRAGLTCVK MFLTNPEGTA NSRVHHLEQA LYYFNIGLTN YVKGCVLSQP
EINNYIQNCT TQLEISKFFY KSSSVFPTTS PVHKLSIFGT IKQKTELVEQ LTINGNFDLG
FKIAQESKLT LPPIYVNALT TMARKKMSSK IEDYLNQLRG CINPEDWELI AMPVFETQCL
ELKEFKSAEK FIPKLYTVYN SVRISILCGK LKTAYLTAVQ HKDRSLIKMV MDEAQKTNQP
VIFKWCQEIL NQ
