Y669_CUPNH
ID Y669_CUPNH Reviewed; 273 AA.
AC P40289; Q0KDV4;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Putative tyrosine-protein phosphatase H16_A0669;
DE EC=3.1.3.48;
DE Flags: Precursor;
GN OrderedLocusNames=H16_A0669;
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.
RX PubMed=8405966; DOI=10.1111/j.1574-6968.1993.tb06453.x;
RA Jendrossek D., Kratzin H.D., Steinbuechel A.;
RT "The Alcaligenes eutrophus ldh structural gene encodes a novel type of
RT lactate dehydrogenase.";
RL FEMS Microbiol. Lett. 112:229-235(1993).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10044};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000305}.
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DR EMBL; AM260479; CAJ91817.1; -; Genomic_DNA.
DR EMBL; Z22737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; WP_010811527.1; NZ_CP039287.1.
DR AlphaFoldDB; P40289; -.
DR SMR; P40289; -.
DR STRING; 381666.H16_A0669; -.
DR PRIDE; P40289; -.
DR EnsemblBacteria; CAJ91817; CAJ91817; H16_A0669.
DR GeneID; 57642765; -.
DR KEGG; reh:H16_A0669; -.
DR eggNOG; COG2365; Bacteria.
DR HOGENOM; CLU_057546_0_0_4; -.
DR OMA; HTIFDFR; -.
DR OrthoDB; 1972497at2; -.
DR Proteomes; UP000008210; Chromosome 1.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR026893; Tyr/Ser_Pase_IphP-type.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR Pfam; PF13350; Y_phosphatase3; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protein phosphatase; Reference proteome; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..273
FT /note="Putative tyrosine-protein phosphatase H16_A0669"
FT /id="PRO_0000066290"
FT ACT_SITE 169
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10044"
SQ SEQUENCE 273 AA; 29325 MW; 111724C25FF66286 CRC64;
MIKWLQRAGC LSAHAVVPQA PAAASVQGRH DLAFDTISNA RDLGGLAGAG GRRVRQGRLY
RSGNPALASA ADLERLQTLG LDMVVDFRSP GEKSPEEAAF GQRFHWVAAP VLEGSMAMDV
LMPRLRASTP AQMDAFMLEV YGDFPVRYRE AFAGFMRTAQ GGKTLLFHCT AGKDRTGFAA
LLLLAALGVA QDDILANYLE SNQRNAQFNQ TALARMAGLG VAPAVMTPLL EVRASYLDAS
MRAIDAGWGS VDNYLRDALE VDVAQLRGHY LAG
