ID   Y672_PYRHO              Reviewed;         309 AA.
AC   O58405;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=UPF0252 protein PH0672;
GN   OrderedLocusNames=PH0672;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0252 family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29763.1; -; Genomic_DNA.
DR   PIR; A71113; A71113.
DR   RefSeq; WP_010884764.1; NC_000961.1.
DR   AlphaFoldDB; O58405; -.
DR   SMR; O58405; -.
DR   STRING; 70601.3257080; -.
DR   EnsemblBacteria; BAA29763; BAA29763; BAA29763.
DR   GeneID; 1442999; -.
DR   KEGG; pho:PH0672; -.
DR   eggNOG; arCOG02164; Archaea.
DR   OMA; PYNNTIQ; -.
DR   OrthoDB; 66569at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR007562; Transglutaminase-like_domain.
DR   Pfam; PF04473; DUF553; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="UPF0252 protein PH0672"
FT                   /id="PRO_0000159560"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  35540 MW;  92FD780636C35517 CRC64;
     MKKVSVIIFI VIMLGIGCLN LNESIKETCP RTSNITQAMS CYIPEDFEIL KGVAEEIPGG
     TIEWKIWNIL EWEEDHLSYD NNKGSDIILK PSEFIKVGEG VCTDYAVLTA GLLLASNISP
     VYLMIFHFME DPTLHAAVAV NISGKLFILD QRLPPKNLDS YLIQFSKLEG KIILFAEMYK
     VEMKKGRVVV SGRKYLDLSN FGFYPGNISL DMLENLLLSE FQRRTNLFPR IDLKTVLPQG
     LKERKVWMIK FENFKLFYDD TFVEQYSNFI ADEILKNEKI KSDISRYSAF WISIKLEGDD
     LIVRLFLGR