ID   Y674_YERPE              Reviewed;         781 AA.
AC   Q8CZS4; Q8CZS5;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative UPF0313 protein YPO0674/y3502/YP_2990;
GN   OrderedLocusNames=YPO0674, y3502/y3503, YP_2990;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM87050.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAM87051.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AE017042; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AL590842; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AL590842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE009952; AAM87050.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE009952; AAM87051.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE017042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q8CZS4; -.
DR   DNASU; 1148449; -.
DR   EnsemblBacteria; AAM87050; AAM87050; y3502.
DR   EnsemblBacteria; AAM87051; AAM87051; y3503.
DR   KEGG; ypk:y3502; -.
DR   KEGG; ypk:y3503; -.
DR   HOGENOM; CLU_018288_1_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   5: Uncertain;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..781
FT                   /note="Putative UPF0313 protein YPO0674/y3502/YP_2990"
FT                   /id="PRO_0000076402"
FT   DOMAIN          368..646
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          681..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        694..710
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..757
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         382
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         386
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
FT   BINDING         389
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   781 AA;  87649 MW;  F2570466C3A27A58 CRC64;
     MSISLIQPER DLFSYQPYWA ECYGTAPFLP MSREEMDILG WDSCDIIVIT GDAYVDHPSF
     GMAIVGRMLE AQGFRVGIIA QPDWTNKHDF MRLGEPNLFF GVTAGNMDSM INRYTADRKL
     RHDDAYTPDN QSGKRPDRAT LVYSQRCKEA YSHVPVLLGG IEASLRRIAH YDYWSDTVRR
     SVIVDAKADM LVYGNGERPL VEVAHRLAAG EKITDIQDVR NTVVMRKTPL PGWSGVDSTR
     LDKPGRIEAI PNPYGEDLPC ATDDISIPEA KPITVRAAKP KPWEKTYVLL PSYEKVKADK
     VLYAHTSRIL HHETNPGCAR ALMQKHGDRY IWINPPAIPL STEEMDSVFA LPYQRVPHPS
     YGKSPIPAYD MIRFSINIMR GCYGGCSFCS ITEHEGRIIQ SRSEDSIIRE IEEIRDKVPG
     FTGIISDLGG PTANMYMLRC QSPRAEQTCR RASCVYPEIC PHMDTNHQPT ISLYRRARDL
     KGIKKILIAS GVRYDLAVED PRYIKELASH HVGGYLKIAP EHTEEGPLSK MMKPGMGSYQ
     RFKELFDTYS KQAGKEQYLI PYFISAHPGT EDKDMVNLAL WLKKNRFRLD QVQNFYPSPL
     ANSTTMYYTG KNPLAKVDYK SEEVVVPKGD RQRRLHKALL RYHDPANWPM LRSALEDMGL
     QHLIGARREC LVPAPTLEEQ REARRALRHH TPALTKHTSI TRQRQPSNRA PAASAGKKAP
     TVANGTSSAH STSANQSTSA NQSTSAAHST LATKKSAGKT GVNKAAVNKP SAGSRGKNRQ
     H