ID   Y6874_DICDI             Reviewed;         436 AA.
AC   Q55EU4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Putative actin-fragmin kinase DDB_G0268748;
DE            EC=2.7.11.-;
GN   ORFNames=DDB_G0268748;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AFK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000004; EAL72963.1; -; Genomic_DNA.
DR   RefSeq; XP_646926.1; XM_641834.1.
DR   AlphaFoldDB; Q55EU4; -.
DR   SMR; Q55EU4; -.
DR   STRING; 44689.DDB0233255; -.
DR   PaxDb; Q55EU4; -.
DR   PRIDE; Q55EU4; -.
DR   EnsemblProtists; EAL72963; EAL72963; DDB_G0268748.
DR   GeneID; 8616614; -.
DR   KEGG; ddi:DDB_G0268748; -.
DR   dictyBase; DDB_G0268748; -.
DR   eggNOG; ENOG502RDNC; Eukaryota.
DR   HOGENOM; CLU_054301_0_0_1; -.
DR   InParanoid; Q55EU4; -.
DR   OMA; DSIYCPF; -.
DR   PhylomeDB; Q55EU4; -.
DR   PRO; PR:Q55EU4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05124; AFK; 1.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   InterPro; IPR015275; Actin-fragmin_kin_cat_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR037469; Put_AFK.
DR   PANTHER; PTHR38737; PTHR38737; 2.
DR   Pfam; PF09192; Act-Frag_cataly; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..436
FT                   /note="Putative actin-fragmin kinase DDB_G0268748"
FT                   /id="PRO_0000367580"
FT   REGION          14..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  49513 MW;  2B2E09480662CD76 CRC64;
     MKTLRELRNK ISFDKNIDSG SSSSNIGGSS SNSSGTTNKR SSGNFNGSSA SSSPSSSTNI
     DYNIPTFSNI QNIDWKSISS VEKIDFGNSN IFLLITFNNN NNINNINNLN CNCVNNNNNN
     ICNNNCINNN NNTNDENPSI INNYNESQIL LKSSSTIAHD VYAYVLEGIL KYPIPEMRLL
     DFSNLEYTEM SYNLLIHSKD DQSLNDFIKS ELEKSFFLIL EYRNNGKRFN ELNHKEYFSG
     SKGGKKFKQL GKIIAFDIFC NNFCKLPSPP LNWNSSTFFS NILCYDSPDK NGWYFSLINS
     NISFLNTSPF TIGYRDHLNR LKLLLFSIFQ NPSTESVQIK LMRDHLLKCQ GIKLSGSSVS
     YLQKGIAKGI KSIVNCINFT VLENTKEKVK NIVKLDNNNI WKKSIDSIYC PFLLDVLNEI
     VIEFANYREK TYFIKA