ID   Y6955_ARTOC             Reviewed;         388 AA.
AC   C5FW52;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Probable aspartic-type endopeptidase MCYG_06955;
DE            EC=3.4.23.-;
DE   Flags: Precursor;
GN   ORFNames=MCYG_06955;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Probable aspartic-type endopeptidase which contributes to
CC       virulence. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   EMBL; DS995706; EEQ34136.1; -; Genomic_DNA.
DR   RefSeq; XP_002844991.1; XM_002844945.1.
DR   AlphaFoldDB; C5FW52; -.
DR   SMR; C5FW52; -.
DR   STRING; 63405.XP_002844991.1; -.
DR   EnsemblFungi; EEQ34136; EEQ34136; MCYG_06955.
DR   GeneID; 9228217; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   HOGENOM; CLU_013253_0_1_1; -.
DR   OMA; HRIYHPE; -.
DR   OrthoDB; 753343at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06097; Aspergillopepsin_like; 1.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034163; Aspergillopepsin-like_cat_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; PTHR47966; 2.
DR   Pfam; PF00026; Asp; 2.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..388
FT                   /note="Probable aspartic-type endopeptidase MCYG_06955"
FT                   /id="PRO_0000406415"
FT   DOMAIN          96..384
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01103"
FT   ACT_SITE        112
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   ACT_SITE        278
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10094"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        209
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        315
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        320
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  43509 MW;  4C6418412969D42D CRC64;
     MMGPFFYFTA YVSLLFAFTQ ALPTINGATA GLFSIEQKQY RSNRVNWPPY ELWRTLRKHH
     RPPPRGMTAV SRIKAYGEHT INGTVEVTPS EYDTEFVNEI TVGNDTLYVD IDTGSSDFWV
     FSSQLPEQSQ RNHRIYHPEE TGTKLPKHTW ESKYGDGTGA AGNVFLDKVN LAGLKVSSQA
     VEAATWVSYE FVDQQTTDGV MGFGFDNFNL TCLKHQAPGF YDFGFIDGTK HVGKPTYLPI
     DSLRGWWETT FNGFSAGDID NSTYRFKAVI GINFELPDTG TTFMLLPKQI TEQYYSTVPA
     SMYDRNNGGW AFPCNTTLPN FTIHINDHKA IVPGEHIRWA QLPGTNTCFG GLQPVNNPPA
     ILGGTFLKSQ FVIFDYDGPK IGFAAQRN