Y7014_PLAF7
ID Y7014_PLAF7 Reviewed; 1058 AA.
AC Q8IC32; A0A5K1K890;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Leucine-rich repeat and coiled-coil domain-containing protein PF3D7_0703800;
GN ORFNames=PF07_0014, PF3D7_0703800;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 129-167, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844506; VWP73979.1; -; Genomic_DNA.
DR RefSeq; XP_001348971.1; XM_001348935.1.
DR AlphaFoldDB; Q8IC32; -.
DR SMR; Q8IC32; -.
DR PRIDE; Q8IC32; -.
DR EnsemblProtists; CAD50809; CAD50809; PF3D7_0703800.
DR GeneID; 2654981; -.
DR KEGG; pfa:PF3D7_0703800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0703800; -.
DR HOGENOM; CLU_289778_0_0_1; -.
DR InParanoid; Q8IC32; -.
DR OMA; EPNDDIS; -.
DR PhylomeDB; Q8IC32; -.
DR Proteomes; UP000001450; Chromosome 7.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Reference proteome; Repeat.
FT CHAIN 1..1058
FT /note="Leucine-rich repeat and coiled-coil domain-
FT containing protein PF3D7_0703800"
FT /id="PRO_0000365116"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 515..544
FT /evidence="ECO:0000255"
FT COILED 872..905
FT /evidence="ECO:0000255"
FT COMPBIAS 7..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 125008 MW; DF209C4E34D261F8 CRC64;
MAIKKKKKET KSKDNNNDNL RNEKKSTNLE NGKYDKKKVE IYEHGIGGIT QNKNDNNKEN
AYDDDIYHDK SEHINVKYLN EKDYEIEKVS KRIYEENSKI KKISLHHKIL KEELETKQLI
EQNDKKKKNS LDYYKKVIIK LKNNINNMEE YTNNITNDIN VLKAHIDDER NERIIYNNNM
KILINEYNSL KKNIQDLNMQ EKEQHKFNTK LKEELKELYK EKENMEKKHR EDFKKLQQKI
KEQKILSYEN KINDLTKEKD KNKMENGEAN KYEDKHNNNN IHNNNNIHND NNICNDNNIC
NDNTIHNDNN ICNDNNICND NNICNDNNIC NDNNIRNNNI ISSNNKIHEK DNMINILNYY
EDEKKKQLQN KIVMLKKLCL RILFINEYQI YNIKKLQENI NNMNNAINSI NLISYKKGDF
DHIIINLNVS KEKNYSLISR INLLNYETNV LKQLIKKMKE KFKHLNLQND EIINLKYDIS
NNMNEKMKHI KTSLLTNQET CNLKKKCFDD CLLYLKQLYT FIKNYENNND KLNIKSQIIN
KDKNLHFNYI HKYNEDILVD ENYINDFLIY IEKYIYSLNF YLPTQNFNYK KYLLHNGSIH
NITLDTHASS KEYLQKEDSS EFNQHGHNLL RDSLNLNEQQ ENKDHLQHEE HTHEEEPKDA
NGDMVNIEDA NGDMVNIEDA NGDMVNIKDA NGDMVNIKDT RGDIENIEDK SGDMENMKEP
NGDMENMKEP NDDIQILKEP NDDIQILKEP NDDIQILKEP NDDIQILKEP NDDIQILKEP
NDDIQILKEP NDDIQILKDP NDDIQILKEP NDDISTINNL TTHLSNENNL MTDLPKVDHK
IKDEIQSEHI LESTNISDDN INKENSLEIP LNYDHTQENI LKNKNNMEDQ NNLLEQNIMT
DQLQNHKECE EFKPHDNKEK NNIINDDTKN LISDDTKNII SDDTKNIISN DTKKILSDDT
KNIISDDTKN IINDDTKNIS NDDIKNISND DIKNIGNDNN KPYNEDHNIV TINDEKANYI
LNHFNSRNIE YDKLKEEIPN ELLNIKYDSS KKSTISTN
