Y7065_DROME
ID Y7065_DROME Reviewed; 1231 AA.
AC Q7YZA2; Q8T031; Q9W386;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Uncharacterized protein CG7065;
GN ORFNames=CG7065;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 727-1231.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-589, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449; SER-451; SER-453;
RP SER-455; TYR-549; SER-573; THR-970 AND SER-972, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL39746.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014298; AAF46448.3; -; Genomic_DNA.
DR EMBL; BT023505; AAY84905.1; -; mRNA.
DR EMBL; AY069601; AAL39746.1; ALT_INIT; mRNA.
DR RefSeq; NP_572529.2; NM_132301.4.
DR AlphaFoldDB; Q7YZA2; -.
DR SMR; Q7YZA2; -.
DR BioGRID; 58299; 4.
DR IntAct; Q7YZA2; 5.
DR iPTMnet; Q7YZA2; -.
DR PaxDb; Q7YZA2; -.
DR PRIDE; Q7YZA2; -.
DR DNASU; 31844; -.
DR EnsemblMetazoa; FBtr0071299; FBpp0071234; FBgn0030091.
DR GeneID; 31844; -.
DR KEGG; dme:Dmel_CG7065; -.
DR UCSC; CG7065-RA; d. melanogaster.
DR FlyBase; FBgn0030091; CG7065.
DR VEuPathDB; VectorBase:FBgn0030091; -.
DR eggNOG; ENOG502QW6J; Eukaryota.
DR GeneTree; ENSGT00530000069079; -.
DR HOGENOM; CLU_264758_0_0_1; -.
DR InParanoid; Q7YZA2; -.
DR OMA; KPEWIEF; -.
DR OrthoDB; 602602at2759; -.
DR PhylomeDB; Q7YZA2; -.
DR BioGRID-ORCS; 31844; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 31844; -.
DR PRO; PR:Q7YZA2; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030091; Expressed in central brain primordium (Drosophila) and 29 other tissues.
DR Genevisible; Q7YZA2; DM.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1231
FT /note="Uncharacterized protein CG7065"
FT /id="PRO_0000372643"
FT REGION 171..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..498
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 449
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 451
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 455
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 549
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 573
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 589
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 970
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 972
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 1231 AA; 136767 MW; D136583CFA7AF69C CRC64;
MSFLPGEPVP PGFEEDVSRT AVIQKQIESY TAGPLIGTEY TIELHEPAQL RPNYFCVLCQ
TCSDGRNVFV HWTSQAHRTK YLQTHFQKAY KELQKLKRTP NSSGDLVTAT GNLVKCIEKH
FGRSRNLITA TGDDFRRYRS KMCSQVRDSF HFDECAGSDF SEEAQRVIRE LKPDESIKSS
MKKNVDGTGD SNKQHDDGNI IALDAISSDD ESFGGSTASV VPVPKGRQKN NLSEDAGGRS
KNQSPPPAGG VNKTQHLPTP KELAIQASKI SQERYKWEKF RCMLEIQLKQ LRSDTEMYES
NPEKHPDYPD EWKQFWNRRY KQLQEEKKCD PNQYDYKPEW ISYWKDRRIV LFDIAVNKIK
KDLKEKFKLG DEDEEKTLEL MERYKIRVAS PRRAPATTNS DNCRKTKPNF RNNRPIVATS
KLPDAVIDIS DDDVDSPPSR SRHSHKRRSI SRSLSPKRGG RRAVRRSRSR SPRRSYNRGS
TRSRSRSMRH RSRSPAHYRG RGRGREPASK ERGSSSRDFG GRHSLQRERE RSSEYYHRNE
GYARSSRGYE SVETFRVLDS RVYPEYKVTK TSSISPTASS NKEKEKEASE PIEEGPLTVV
SVLRMLSAVE EHLGSLGPKA LNLLSKALAM ELVKPNAAED LLRNEDNCVF LETTKEKLKG
ILIAEVLDDP QKVRVIKKLI TNIAEIIYQA TFKGTNDAVD VKVKANANPA PIQLPFDRNL
VAPKLANALV LNGYNNVSTG DMNNLLHMLT LLMKTDKQRR QLDNNNGLKF EEIKVKLGLQ
NNPSPDDMGI DLDELMKEVE HQLHKESVDI VNKPTGAPAK VQAADTVGGS TGLESLTDSD
LQTLLQNFKF LSNEEQVHLI GHLRKLEVQD PSRVDRLRKY VNLVELRGDG ESCSDFLARV
VKIGGASKAK PATKFKASVM GGRTSSAMAA SSASATAPKV GHSMLSAQRP NLDRDMSSMP
INKQRRGRNT PSIMLDDDDE EDDDYNFDDL VMKACDSNGS ASAGGGGGVV GAGVHNKPGV
PPIIGVESSP NALTFKPAAA TKISLKDTEN IIANLMGTLS KNGTSGGSPV GGNRNYMMNQ
QHGAPNAQNA PNLGQNPGQN LGQKQPGAGY SNAGYPGQQQ QQQQQQQHGR NFGQEAQPLM
SGLSGGPNAN HYPNQQGYGG YHPFAGNGVQ QNYGGMVPPG PGGYVGPPPN PWASNVPPQP
PFNQMPQNFM GAQQQQQQQQ PHFNNMFGGR H
