ID   Y709_METJA              Reviewed;         450 AA.
AC   Q58119;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Uncharacterized transporter MJ0709;
GN   OrderedLocusNames=MJ0709;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98703.1; -; Genomic_DNA.
DR   PIR; E64388; E64388.
DR   AlphaFoldDB; Q58119; -.
DR   SMR; Q58119; -.
DR   STRING; 243232.MJ_0709; -.
DR   TCDB; 2.A.66.1.26; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   EnsemblBacteria; AAB98703; AAB98703; MJ_0709.
DR   KEGG; mja:MJ_0709; -.
DR   eggNOG; arCOG01731; Archaea.
DR   HOGENOM; CLU_012893_0_1_2; -.
DR   InParanoid; Q58119; -.
DR   OMA; EFWILLK; -.
DR   PhylomeDB; Q58119; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..450
FT                   /note="Uncharacterized transporter MJ0709"
FT                   /id="PRO_0000164254"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  48495 MW;  52EFE11132C4B79A CRC64;
     MKNVEILLDD PKKAVIEVSK PIIVATFIES IYSLVDSIWV SGLGADALAA VGASFPILIS
     IYAVSWGLSI GISSGIARRV GAKNKEEADK VANHAIILAL IAGILYIIAV YPNLDTLFSL
     MGTYGDCKSL AIKYSSILVL GTVIFTICDA LYGIFRGEGN TKIVMIASVI GTLTNIILDP
     IFIYMLNLGI SGASYATLIA IIISLLILAY ELFIKKSCYV TVKLSKFKPD LKIIADLIRV
     GIPSALIEIT VAVSFFIMTS IIMMVGDSRG LAVYTGALRI TEFGFIPMLG LASGATSVIG
     ATYGARSFEK LKTAYFYTIK IGVLMEIIIV ALIMLLSPIL AYLFTYTKTS MGIHEELVKA
     LRIVPLYLLF TPFILTTSAM FQGIGKGEKS LIISIFRSLI CHISYAYLFA VILGLGMFGI
     YSGLVVGEFT AGIFAFLFGV LAIKALIKSK