Y714_MYCCT
ID Y714_MYCCT Reviewed; 302 AA.
AC P45614; Q2SRD9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase MCAP_0714;
DE EC=5.4.99.-;
DE AltName: Full=ORF2;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=MCAP_0714;
OS Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343
OS / NCTC 10154).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=340047;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=California kid / ATCC 27343 / NCTC 10154;
RA Glass J.I., Lartigue C., Pfannkoch C., Baden-Tillson H., Smith H.O.,
RA Venter J.C., Roske K., Wise K.S., Calcutt M.J., Nelson W.C., Nierman W.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-145.
RX PubMed=8253782; DOI=10.1016/s0021-9258(19)74345-2;
RA Zhu P.-P., Reizer J., Reizer A., Peterkofsky A.;
RT "Unique monocistronic operon (ptsH) in Mycoplasma capricolum encoding the
RT phosphocarrier protein, HPr, of the phosphoenolpyruvate:sugar
RT phosphotransferase system. Cloning, sequencing, and characterization of
RT ptsH.";
RL J. Biol. Chem. 268:26531-26540(1993).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; CP000123; ABC01670.1; -; Genomic_DNA.
DR EMBL; L22432; AAA16215.1; -; Unassigned_DNA.
DR PIR; C49683; C49683.
DR RefSeq; WP_011387558.1; NC_007633.1.
DR AlphaFoldDB; P45614; -.
DR SMR; P45614; -.
DR EnsemblBacteria; ABC01670; ABC01670; MCAP_0714.
DR GeneID; 23778332; -.
DR KEGG; mcp:MCAP_0714; -.
DR HOGENOM; CLU_016902_1_0_14; -.
DR OMA; HAFLVKF; -.
DR OrthoDB; 1714699at2; -.
DR PhylomeDB; P45614; -.
DR Proteomes; UP000001928; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase; RNA-binding.
FT CHAIN 1..302
FT /note="Uncharacterized RNA pseudouridine synthase
FT MCAP_0714"
FT /id="PRO_0000162745"
FT DOMAIN 13..89
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT ACT_SITE 141
FT /evidence="ECO:0000250"
SQ SEQUENCE 302 AA; 35942 MW; 204FFBD6307EA7D8 CRC64;
MTKFIVNKND QNQTLFKFLK KTFKTTPISV IYKWIRNKSI KINSKRVNDK NYLLKINDVV
EVYDSNKPII RDQFNYISNV NLDIVYEDNN ILIVNKPNNL EMHSIYNLCL DDMVKSYLVD
KKEYDIYLEN SFVISHVHRL DKLTSGLVIY AKNKISSIIL TNAFKTKDQI NKYYYALTSY
DWNLNDFLQV NGYINYNSNT QKADFSLVEK NNYKYCQTEF KLVNKNLILV KLITGKKHQI
RSVLSFYNNP ILNDFRYNGK KENDQKMIYL AAFKIEFKSL KKPLDYLNNK VIIKNPDWIS
RR
