ID   Y7151_DICDI             Reviewed;         366 AA.
AC   Q86AF0; Q55AZ1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=PA-phosphatase related-family protein DDB_G0271516;
GN   ORFNames=DDB_G0271516;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71622.1; -; Genomic_DNA.
DR   RefSeq; XP_645555.1; XM_640463.1.
DR   AlphaFoldDB; Q86AF0; -.
DR   STRING; 44689.DDB0232324; -.
DR   PaxDb; Q86AF0; -.
DR   EnsemblProtists; EAL71622; EAL71622; DDB_G0271516.
DR   GeneID; 8618012; -.
DR   KEGG; ddi:DDB_G0271516; -.
DR   dictyBase; DDB_G0271516; -.
DR   eggNOG; KOG3030; Eukaryota.
DR   HOGENOM; CLU_757429_0_0_1; -.
DR   InParanoid; Q86AF0; -.
DR   OMA; FSWNDAT; -.
DR   PhylomeDB; Q86AF0; -.
DR   Reactome; R-DDI-1660661; Sphingolipid de novo biosynthesis.
DR   Reactome; R-DDI-2029485; Role of phospholipids in phagocytosis.
DR   Reactome; R-DDI-419408; Lysosphingolipid and LPA receptors.
DR   PRO; PR:Q86AF0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR043216; PA_PP_rel.
DR   PANTHER; PTHR10165; PTHR10165; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..366
FT                   /note="PA-phosphatase related-family protein DDB_G0271516"
FT                   /id="PRO_0000367484"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          308..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  41464 MW;  CCA1810EF4366E64 CRC64;
     MENSGLLFNN DETIINKKIK KIIYENQYDK PLFYDIDLRK NNKKLIYLLD WFCVVVLLVI
     GSILLLKVPV RGRLFRLNDE SISYPKLEEI IPLGLLIPLV TAVPFAMILL ISIIFKRDIN
     DFHHSLLGFL QSISVTILLT GSFKVFIGGL RPSFLEFCKP TKESIVAGNP PVGYGAIYYD
     RSICTESEFI VNDGLSAYPS GHSSIAASCF GFLALYLLAR LKCFDNRGHI IIYLLIIGCL
     ITAGLIGISR VADYRHTFLN VLAGWSIGLL ISLSCYRLNF SSLFGRDNHI SIHSHWLTYW
     DYHNNNNNSN SNNNNNNNNN NNNNNNNNNN NNNNKKDNIN NNSTKTQNNF ESYQSPNGIP
     LNELQN