Y7165_DICDI
ID Y7165_DICDI Reviewed; 833 AA.
AC Q76P07; Q54ZS9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Probable serine/threonine-protein kinase DDB_G0277165;
DE EC=2.7.11.1;
GN ORFNames=DDB_G0277165;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL68768.1; -; Genomic_DNA.
DR RefSeq; XP_642787.1; XM_637695.1.
DR AlphaFoldDB; Q76P07; -.
DR SMR; Q76P07; -.
DR STRING; 44689.DDB0229364; -.
DR PaxDb; Q76P07; -.
DR PRIDE; Q76P07; -.
DR EnsemblProtists; EAL68768; EAL68768; DDB_G0277165.
DR GeneID; 8620980; -.
DR KEGG; ddi:DDB_G0277165; -.
DR dictyBase; DDB_G0277165; -.
DR eggNOG; KOG0588; Eukaryota.
DR HOGENOM; CLU_340804_0_0_1; -.
DR InParanoid; Q76P07; -.
DR OMA; KHINPRT; -.
DR PRO; PR:Q76P07; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..833
FT /note="Probable serine/threonine-protein kinase
FT DDB_G0277165"
FT /id="PRO_0000367468"
FT DOMAIN 9..262
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DOMAIN 288..329
FT /note="UBA"
FT REGION 338..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 133
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 15..23
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 833 AA; 93467 MW; 51E64036C90C0F94 CRC64;
MEIHSVGPFI IGKTLGQGTT GKVKLGFHKD TGFKVGIKII NKELLINKPS MRRKIEREIV
LMKLIDHPNA MKMYEVYETS KYLFLILEYV EGGELFDYLV EKGGLESGEA LFFFQQIIIG
LEYCHSRNIC HRDLKPENLL LSGDKRIKIA DFGMGSIVRK DMLLHTSCGS PHYASPEVVS
GIDYDGQKAD VWSCGVILYA LLTGKLPFDD ENIRRLLNKV KNGAFSMPPY IHKDAQDLLT
KMLTVDPSKR ISIKEIKEHP WFVSNFNQFQ KATPVEEINA EPLVDYSQID EDIFRSLMAL
GVGTIDEVKQ QLVSNQKSAT LIYYRLLEER KKFDSDVNKY GYKPKETRRN SLSDMSLKKI
FSGSNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNINI NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNSAVGKSND SSSQQPPHIQ QPHSQQIPSN STSQESMQIS PSNSANNMAI
QQPIINNNNN NNNNNNNINN NINNNINNNI NNNSNNVNRP TSEGLLKQAL QQHHQQQQQQ
FNGNNNNNTM NVQPLTMSAS SSSSSSSTTP SLSPNSSTTS STSTSPQLSA IKPDHYQRRG
SMTASTNPAT SPTMSHRGKT SSPIEITSKV RKLKISESQS NTPNSPIIGS SPKKSWFSYF
FSKNSSSNNL NAANGSAPSS PSLQSNGVGQ LQTTQANYVI ESKIDVNLIY VNLEKIIKKY
GFELKYQQQQ QQQNIKHCIV RSHHINSDGT PQFECEIEIK PSTFINPVSP SKQHHHHHHQ
QQQPQQQQMP PLNLNGGQNI NHDQGFRVSI IHKSGSQHKF NNFTSSLEQI LTI
