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Y723_CHLP8
ID   Y723_CHLP8              Reviewed;         327 AA.
AC   O50310; B3QMI9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase Cpar_0723;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=Cpar_0723;
OS   Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) (Chlorobium vibrioforme
OS   subsp. thiosulfatophilum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX   NCBI_TaxID=517417;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Petersen B.L., Moeller M.G., Stummann B.M., Henningsen K.W.;
RT   "Clustering of genes with function in the biosynthesis of
RT   bacteriochlorophyll and heme in the green sulfur bacterium Chlorobium
RT   vibrioforme.";
RL   Hereditas 125:93-96(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 263 / NCIMB 8327;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobaculum parvum NCIB 8327.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACF11142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z83933; CAB06297.1; -; Genomic_DNA.
DR   EMBL; CP001099; ACF11142.1; ALT_INIT; Genomic_DNA.
DR   PIR; T17190; T17190.
DR   AlphaFoldDB; O50310; -.
DR   SMR; O50310; -.
DR   STRING; 517417.Cpar_0723; -.
DR   EnsemblBacteria; ACF11142; ACF11142; Cpar_0723.
DR   KEGG; cpc:Cpar_0723; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_4_3_10; -.
DR   OMA; AHPSPGW; -.
DR   Proteomes; UP000008811; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; RNA-binding.
FT   CHAIN           1..327
FT                   /note="Uncharacterized RNA pseudouridine synthase
FT                   Cpar_0723"
FT                   /id="PRO_0000162732"
FT   DOMAIN          12..84
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        137
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   327 AA;  36736 MW;  549696105086A76E CRC64;
     MTLDVSKVQT PMRIDRYLTQ QVENMTRNKV QAAIEEGRVL VNGKPVKSNY RVKSCDHIHL
     TFLRPPAPEL APEDIPITIL YEDDDLMVID KEAGMVVHPA FGNWTGTLAN AILHHLGKDA
     DELDKTEMRP GIVHRLDKDT SGLIIIAKNP TALHKLARQF ANRQVEKVYK AIVWGVPKAE
     SGTIKTNIGR SHKNRKVMAN FPYEGAEGKH AITDYQVVED LGYFSLMDVT LHTGRTHQIR
     VHLQHLGHSI LGDETYGGAT PRTLPFSKSE PFTRNLLELM SRQALHAQTL RFRQPTTGEP
     LSFSAPLPED MELVLEKIRT VMTASQS
 
 
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