ID   Y7243_DICDI             Reviewed;         423 AA.
AC   Q86K46; Q54ZW9;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0277243;
GN   ORFNames=DDB_G0277243;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000019; EAL68807.1; -; Genomic_DNA.
DR   RefSeq; XP_642747.1; XM_637655.1.
DR   AlphaFoldDB; Q86K46; -.
DR   SMR; Q86K46; -.
DR   STRING; 44689.DDB0237657; -.
DR   PaxDb; Q86K46; -.
DR   EnsemblProtists; EAL68807; EAL68807; DDB_G0277243.
DR   GeneID; 8620937; -.
DR   KEGG; ddi:DDB_G0277243; -.
DR   dictyBase; DDB_G0277243; trafF.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q86K46; -.
DR   OMA; CENHLNT; -.
DR   PhylomeDB; Q86K46; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q86K46; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..423
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0277243"
FT                   /id="PRO_0000393720"
FT   DOMAIN          287..411
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         20..66
FT                   /note="RING-type; degenerate"
FT   ZN_FING         124..179
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         180..237
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
SQ   SEQUENCE   423 AA;  49254 MW;  973D444CBB69C5F0 CRC64;
     MIDYKINEIL VKQLNDDYNC SICVDPVLNS LPLEQHQALS CKNGHLLCQA CWGKQLALRK
     ECCICKIKVE SISELCRNIF LEKGFRNKKV HCPNGFENFK VDEKLIKDES DGCKSVITID
     QLESHLRECE FVFIECPNDP IRCKDKFRKN QTDKHMNKCQ YVTINCEHCK EPVIKNDMPT
     HIENDCSIIS LECEFCKDKF GRRSLENHIA NECPNVVIDC PHKEGGCTAR IKRCYLSQHL
     TEEDNHIRYM QKIIEKHRIQ VEESDRIIKK LRVDYKELEK RVEITSRYKG NWTIENWSQK
     LTHYPNNERL KSPYFCIGSK SFYVGLYPNG FNQTNAGFMS IFLHLYEKPS TSTTVVRFSF
     ELLHSDPTKS LKFEKSNKYT ENKGSGFSQF IDIKMINNFI IDGKLTINID VEVIPPSSSL
     VTK