ID   Y7281_DICDI             Reviewed;         417 AA.
AC   Q54KL0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Citrate synthase-related protein DDB_G0287281;
GN   ORFNames=DDB_G0287281;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
CC   -!- CAUTION: Although highly related to the citrate synthase family, lacks
CC       the conserved active His at position 264 which is replaced by an Asn
CC       residue. {ECO:0000305}.
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DR   EMBL; AAFI02000099; EAL63802.1; -; Genomic_DNA.
DR   RefSeq; XP_637307.1; XM_632215.1.
DR   AlphaFoldDB; Q54KL0; -.
DR   SMR; Q54KL0; -.
DR   STRING; 44689.DDB0220637; -.
DR   PaxDb; Q54KL0; -.
DR   EnsemblProtists; EAL63802; EAL63802; DDB_G0287281.
DR   GeneID; 8626044; -.
DR   KEGG; ddi:DDB_G0287281; -.
DR   dictyBase; DDB_G0287281; -.
DR   eggNOG; KOG2617; Eukaryota.
DR   HOGENOM; CLU_025068_2_1_1; -.
DR   InParanoid; Q54KL0; -.
DR   OMA; LTYCGYD; -.
DR   PhylomeDB; Q54KL0; -.
DR   PRO; PR:Q54KL0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0050440; F:2-methylcitrate synthase activity; IBA:GO_Central.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IBA:GO_Central.
DR   GO; GO:0019679; P:propionate metabolic process, methylcitrate cycle; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..417
FT                   /note="Citrate synthase-related protein DDB_G0287281"
FT                   /id="PRO_0000388245"
FT   REGION          284..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  47706 MW;  40C5941809D631BA CRC64;
     MSNESKICLV NEDSIYYRGY DIKDLTAVSS FEEVSFLLIY GELPTERELI EYRSELQHYR
     YIPESLKQVL ERIPIYAHPI DVLKTACSFY STISPESKQN DIYRISNRLI GSFPSILFYW
     YHFSSNGIRI NTLTEVNDSF ARHFLKLLNR GNNNNINNNN KFTTEQDEEP ILEYVKALDV
     SLILYAEHGI ETASTFSCRL SASTGSDVYS CIGSSIGTMK GVLDDGGSSE AVMYLLQPMK
     SPEDADKKIM KMINNNQRII GFSNEFDQRT PIIKEWSKQL SIINKNNNNN NNNNNNNNNN
     NNNNNNNNNS EDDDDDNSLQ TISERVEEIM FDVLKVHANV DFYNATVFHQ SNIPTLLFSA
     ISVIARTTGW MANIIEQRCQ SKNSLPSLIY TGSDPIPFTP INERVYYHNF KIPNSNL