ID   Y734_FUSNN              Reviewed;         568 AA.
AC   Q8R682;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=UPF0313 protein FN0734 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=FN0734;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
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DR   EMBL; AE009951; AAL94930.1; -; Genomic_DNA.
DR   RefSeq; NP_603631.1; NC_003454.1.
DR   AlphaFoldDB; Q8R682; -.
DR   STRING; 190304.FN0734; -.
DR   PRIDE; Q8R682; -.
DR   EnsemblBacteria; AAL94930; AAL94930; FN0734.
DR   KEGG; fnu:FN0734; -.
DR   PATRIC; fig|190304.8.peg.1297; -.
DR   eggNOG; COG1032; Bacteria.
DR   HOGENOM; CLU_018288_2_0_0; -.
DR   InParanoid; Q8R682; -.
DR   OMA; TCMYYTG; -.
DR   BioCyc; FNUC190304:G1FZS-1320-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..568
FT                   /note="UPF0313 protein FN0734"
FT                   /id="PRO_0000076386"
FT   DOMAIN          289..562
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          546..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         303
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         307
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         310
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   568 AA;  65012 MW;  9740EE642B424640 CRC64;
     MKFLPTTKEE MKNLGWDSID VLLISGDTYL DTSYNGSVLV GKWLVEHGFK VGIIAQPEVD
     VPDDITRLGE PNLFFAVSGG CVDSMVANYT ATKKRRQQDD FTPGGVNNKR PDRAVLVYSN
     MIRRFFKGTT KKIVISGIES SLRRITHYDY WTNKLRKPIL FDAKADILSY GMGEMSMLQL
     ANALKNGEDW KNIKGLCYLS KEMKQDYLSL PSHSECLADK DNFIEAFHTF YLNCDPITAK
     GLCQKCDDRY LIQNPPSESY SEEIMDKIYS MEFARDVHPY YKKMGAVRAL DTIKYSVTTH
     RGCYGECNFC AIAIHQGRTI MSRSQSSIVE EVKNIAGTPK FHGNISDVGG PTANMYGLEC
     KKKLKLGACP DRRCLYPKKC LHLQVNHNNQ VELLKKLKKI PNIKKIFIAS GIRYDMILDD
     NKCGQMYLKE IIKDHISGQM KIAPEHTEDK ILGLMGKDGK SCLNEFKNQF YKINNELGKK
     QFLTYYLIAA HPGCKDKDMM DLKRYASQEL RVNPEQVQIF TPTPSTYSTL MYYTEKDPFT
     NQKLFVEKDN GKKQKQKDIV TEKRKNRK