ID   Y736_HAEIN              Reviewed;         508 AA.
AC   P44849;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Uncharacterized sodium-dependent transporter HI_0736;
GN   OrderedLocusNames=HI_0736;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Putative sodium-dependent transporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22395.1; -; Genomic_DNA.
DR   PIR; E64089; E64089.
DR   RefSeq; NP_438895.1; NC_000907.1.
DR   RefSeq; WP_005693140.1; NC_000907.1.
DR   AlphaFoldDB; P44849; -.
DR   SMR; P44849; -.
DR   STRING; 71421.HI_0736; -.
DR   EnsemblBacteria; AAC22395; AAC22395; HI_0736.
DR   KEGG; hin:HI_0736; -.
DR   PATRIC; fig|71421.8.peg.771; -.
DR   eggNOG; COG0733; Bacteria.
DR   HOGENOM; CLU_006855_3_3_6; -.
DR   OMA; NLWGFAY; -.
DR   PhylomeDB; P44849; -.
DR   BioCyc; HINF71421:G1GJ1-774-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 2.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..508
FT                   /note="Uncharacterized sodium-dependent transporter
FT                   HI_0736"
FT                   /id="PRO_0000214818"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   508 AA;  55177 MW;  5CC50526DE854BB9 CRC64;
     MAHSAPKAQK RETFSGRRAF ILAAIGSAVG LGNIWRFPYT TYENGGGAFI IPYLIALLTA
     GIPLLFLDYA IGHRHRGGAP LSYRRFSPHF EVFGWWQMMV NVIIGLYYAV VLGWAASYTY
     FSFTGAWGDK PIDFFIGKFL KMGDIKNGIS FEFVGMVTAP LIAMWIVALG VLSMGVQKGI
     AKVSSVLMPV LVVMFMVLVI YSLFLPGAAK GLDALFTPDW SKLSNPSVWI AAYGQIFFSL
     SIGFGIMVTY ASYLKKESDL TGSGLVVGFA NSSFEVLAGI GVFAALGFIA TAQGQEVSEV
     AKGGIGLAFF AFPTIINKAP FGEVLGMLFF GSLTFAALTS FISVIEVIIS AIQDKIRISR
     GKVTFIVGVP MMLVSVILFG TTTGLPMLDV FDKFVNYFGI VAVAFASLIA IVANEKLGLL
     GNHLNETSSF KVGFFWRLCI VLTSGVLAFM LFSEGAKVFS EGYEGYPNWF VNTFGWGMSI
     SLLVVACFLS RLKWKSETKL TIDETKGE