ID   Y739_MYCTA              Reviewed;         318 AA.
AC   A5U0B7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_0739;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_0739;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ72467.1; -; Genomic_DNA.
DR   RefSeq; WP_003403717.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U0B7; -.
DR   SMR; A5U0B7; -.
DR   STRING; 419947.MRA_0739; -.
DR   EnsemblBacteria; ABQ72467; ABQ72467; MRA_0739.
DR   KEGG; mra:MRA_0739; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NAFNWEE; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..318
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MRA_0739"
FT                   /id="PRO_0000361232"
FT   BINDING         135
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         164..165
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   318 AA;  34950 MW;  F25150B40E9D1BE5 CRC64;
     MTQTGSARFE GDSWDLASSV GLTATMVAAA RAVAGRAPGA LVNDQFAEPL VRAVGVDFFV
     RMASGELDPD ELAEDEANGL RRFADAMAIR THYFDNFFLD ATRAGIRQAV ILASGLDSRA
     YRLRWPAGTI VFEVDQPQVI DFKTTTLAGL GAAPTTDRRT VAVDLRDDWP TALQKAGFDN
     AQRTAWIAEG LLGYLSAEAQ DRLLDQITAQ SVPGSQFATE VLRDINRLNE EELRGRMRRL
     AERFRRHGLD LDMSGLVYFG DRTDARTYLA DHGWRTASAS TTDLLAEHGL PPIDGDDAPF
     GEVIYVSAEL KQKHQDTR