ID   Y746_CHLPN              Reviewed;         531 AA.
AC   Q9Z7F9;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=UPF0159 protein CPn_0746/CP_1126/CPj0746/CpB0774;
GN   OrderedLocusNames=CPn_0746, CP_1126, CPj0746, CpB0774;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UPF0159 family. {ECO:0000305}.
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DR   EMBL; AE001363; AAD18885.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38892.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98953.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98703.1; -; Genomic_DNA.
DR   PIR; G86583; G86583.
DR   PIR; H72040; H72040.
DR   RefSeq; NP_224942.1; NC_000922.1.
DR   RefSeq; WP_010883384.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z7F9; -.
DR   SMR; Q9Z7F9; -.
DR   STRING; 115711.CP_1126; -.
DR   EnsemblBacteria; AAD18885; AAD18885; CPn_0746.
DR   EnsemblBacteria; AAF38892; AAF38892; CP_1126.
DR   GeneID; 45050800; -.
DR   KEGG; cpa:CP_1126; -.
DR   KEGG; cpj:CPj0746; -.
DR   KEGG; cpn:CPn_0746; -.
DR   KEGG; cpt:CpB0774; -.
DR   PATRIC; fig|115713.3.peg.823; -.
DR   eggNOG; COG1351; Bacteria.
DR   HOGENOM; CLU_024745_0_0_0; -.
DR   OrthoDB; 809519at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0050797; F:thymidylate synthase (FAD) activity; IEA:InterPro.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.170; -; 2.
DR   InterPro; IPR003669; Thymidylate_synthase_ThyX.
DR   InterPro; IPR036098; Thymidylate_synthase_ThyX_sf.
DR   PANTHER; PTHR34934; PTHR34934; 1.
DR   Pfam; PF02511; Thy1; 2.
DR   SUPFAM; SSF69796; SSF69796; 2.
DR   PROSITE; PS51331; THYX; 2.
PE   3: Inferred from homology;
KW   Repeat.
FT   CHAIN           1..531
FT                   /note="UPF0159 protein CPn_0746/CP_1126/CPj0746/CpB0774"
FT                   /id="PRO_0000220643"
FT   DOMAIN          38..274
FT                   /note="ThyX 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
FT   DOMAIN          309..511
FT                   /note="ThyX 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
SQ   SEQUENCE   531 AA;  61146 MW;  BA535F53D443843F CRC64;
     MLGKEEEFTC KQKQCLSHFV TNLTSDVFAL KNLPEVVKGA LFSKYSRSVL GLRALLLKEF
     LSNEEDGDVC DEAYDFETDV QKAADFYQRV LDNFGDDSVG ELGGAHLAME NVSILAAKVL
     EDARIGGSPL EKSTRYVYFD QKVRGEYLYY RDPILMTSAF KDMFLGTCDF LFDTYSALIP
     QVRAYFEKLY PKDSKTPASA YATSLRAKVL DCIRGLLPAA TLTNLGFFGN GRFWQNLIHK
     LQGHNLAELR RLGDESLTEL MKVIPSFVSR AEPHHHHHQA MMQYRRALKE QLKGLAEQAT
     FSEEMSSSPS VQLVYGDPDG IYKVAAGFLF PYSNRSLTDL IDYCKKMPHE DLVQILESSV
     SARENRRHKS PRGLECVEFG FDILADFGAY RDLQRHRTLT QERQLLSTHH GYNFPVELLD
     TPMEKSYREA MERANETYNE IVQEFPEEAQ YMVPMAYNIR WFFHVNARAL QWICELRSQP
     QGHQNYRTIA TGLVREVVKF NPMYELFFKF VDYSDIDLGR LNQEMRKEPT T