ID   Y746_STAAM              Reviewed;         356 AA.
AC   Q7A2V2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Uncharacterized membrane protein SAV0746;
GN   OrderedLocusNames=SAV0746;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BA000017; BAB56908.1; -; Genomic_DNA.
DR   RefSeq; WP_000460983.1; NC_002758.2.
DR   AlphaFoldDB; Q7A2V2; -.
DR   SMR; Q7A2V2; -.
DR   PaxDb; Q7A2V2; -.
DR   EnsemblBacteria; BAB56908; BAB56908; SAV0746.
DR   KEGG; sav:SAV0746; -.
DR   HOGENOM; CLU_000445_11_1_9; -.
DR   OMA; FKQYKFQ; -.
DR   PhylomeDB; Q7A2V2; -.
DR   BioCyc; SAUR158878:SAV_RS04095-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:InterPro.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR011620; Sig_transdc_His_kinase_LytS_TM.
DR   Pfam; PF07694; 5TM-5TMR_LYT; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   TIGRFAMs; TIGR00254; GGDEF; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="Uncharacterized membrane protein SAV0746"
FT                   /id="PRO_0000286956"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          218..353
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00095"
SQ   SEQUENCE   356 AA;  40345 MW;  E687E1CD5FFA8989 CRC64;
     MFEAFIYNIS VIVAGIYLFH RLQYSENKRM VFSKAYVTVL MTIVSLLLSV YPIPYREDYL
     IHLTFVPLLF LGRFTNMVYT LSATVIVAIV EIVVFNNSIM YGVTLIVIAA VTSAIGPFLK
     QNDVLSLLIL NVVTIIILFG VALVSPIYTL SEVIILIPIS LIITLASAIT FVDIWHFFSL
     VNRYENEDKY DYLTGLGNVK EFDRHLNEIS RKAEKEHQSI ALLLIDIDGF KDVNDTYSHK
     SGDAVLKQMS QLLKNYVPNQ FKIFRNGGEE FSVVIHNYSL DQSVKLAENI RSGVEKSSFH
     LPNKEVIKLS VSIGVGYLTD DDPKSQRKVF KDADDMVHVA KNQGRNKVMF NPIINL