ID   Y751_MYCTU              Reviewed;         367 AA.
AC   P9WFI7; L0T4P3; P95074; Q7D9E1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0726c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv0726c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   SEQUENCE REVISION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA   Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT   "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT   H37Rv.";
RL   Microbiology 148:2967-2973(2002).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43471.1; -; Genomic_DNA.
DR   PIR; A70645; A70645.
DR   RefSeq; NP_215240.1; NC_000962.3.
DR   RefSeq; WP_003403691.1; NZ_NVQJ01000007.1.
DR   AlphaFoldDB; P9WFI7; -.
DR   SMR; P9WFI7; -.
DR   STRING; 83332.Rv0726c; -.
DR   PaxDb; P9WFI7; -.
DR   DNASU; 888552; -.
DR   GeneID; 45424691; -.
DR   GeneID; 888552; -.
DR   KEGG; mtu:Rv0726c; -.
DR   TubercuList; Rv0726c; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; RMADNMA; -.
DR   PhylomeDB; P9WFI7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..367
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv0726c"
FT                   /id="PRO_0000361242"
FT   REGION          348..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         137
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         166..167
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   367 AA;  40876 MW;  5FF038903881804A CRC64;
     MTYTGSIRCE GDTWDLASSV GATATMVAAA RAMATRAANP LINDQFAEPL VRAVGVDVLT
     RLASGELTAS DIDDPERPNA SMVRMAEHHA VRTKFFDEFF MDATRAGIRQ VVILASGLDS
     RAYRLAWPAQ TVVYEIDQPQ VMEFKTRTLA ELGATPTADR RVVTADLRAD WPTALGAAGF
     DPTQPTAWSA EGLLRYLPPE AQDRLLDNVT ALSVPDSRFA TESIRNFKPH HEERMRERMT
     ILANRWRAYG FDLDMNELVY FGDRNEPASY LSDNGWLLTE IKSQDLLTAN GFQPFEDEEV
     PLPDFFYVSA RLQRKHRQYP AHRKPAPSWR HTACPVNELS KSAAYTMTRS DAHQASTTAP
     PPPGLTG