ID   Y751_OCEIH              Reviewed;         579 AA.
AC   Q8ES91;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Putative adenine deaminase OB0751;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   OrderedLocusNames=OB0751;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000305}.
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DR   EMBL; BA000028; BAC12707.1; -; Genomic_DNA.
DR   RefSeq; WP_011065159.1; NC_004193.1.
DR   AlphaFoldDB; Q8ES91; -.
DR   SMR; Q8ES91; -.
DR   STRING; 221109.22776431; -.
DR   EnsemblBacteria; BAC12707; BAC12707; BAC12707.
DR   KEGG; oih:OB0751; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; IEGHFPG; -.
DR   OrthoDB; 751534at2; -.
DR   PhylomeDB; Q8ES91; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..579
FT                   /note="Putative adenine deaminase OB0751"
FT                   /id="PRO_0000142448"
SQ   SEQUENCE   579 AA;  66114 MW;  E132C1895CAFA265 CRC64;
     MENGRNWRNR ELRQHVKVID GTVSPTLLLK NATYLNVHTK QWLEANIWIY KDRIIYVGEK
     LPNQSQETEV YDCEGRFVVP GYIEPHAHPF QLANPEITAM HAAKTGTTTL VNDNLTWYLL
     TNKKKAFSII DQFNKLPISM FWWSRYDSQT TLQEENHFIN TNDVLDWINH PSVVQGGELT
     DWPSLLAGDD RLLYWIQETK RNGKPIEGHL PGASLRTLTK MKLLGISADH EAMTGKDVMN
     RLQLGYMVGL RYSPIRPDLP AILEELLESG LTTFDQLTFT MDGPTPYFMK DGVINTCIQI
     AIDKGIPLED AYRMGSFHAA KHLRMDEELG SIAPGRIAHI NILQEKENPN PIGVLAKGEW
     IVKETKEIDI PSIIDWSKYE INEMNIDWNL TEDDLQFSVP VGMDVVNDVI IKPYTIDSDV
     SFEELNEEKG EQFILLIDRK GKWRVNTIIR GFAPKLGALI SSYSASGDII IIGNSKKDIF
     IAWNRLKEIK GGIILVNNGE ILTEIPLTLG GSLPNEPMEQ MIKYDKQLKD TLQKYGFAFY
     DPVYSLLFLS AFHLPFFRIT QKGLLDVKNR DILFPATMR