Y752_CALS4
ID Y752_CALS4 Reviewed; 112 AA.
AC Q8RBR1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Putative RNase TTE0752;
DE EC=3.1.-.- {ECO:0000250|UniProtKB:Q8ECH6};
DE AltName: Full=Putative toxin TTE0752;
GN OrderedLocusNames=TTE0752;
OS Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=273068;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
CC -!- FUNCTION: Probable toxic component of a putative type VII toxin-
CC antitoxin (TA) system, probably an RNase. Probably neutralized by
CC cognate antitoxin TTE0751. Neutralization may be due to AMPylation by
CC TTE0751. {ECO:0000250|UniProtKB:Q8ECH6}.
CC -!- SUBUNIT: Homodimer, probably forms a complex with cognate antitoxin
CC TTE0751. {ECO:0000250|UniProtKB:Q8ECH6}.
CC -!- PTM: Modified by cognate antitoxin TTE0751; probably at least 2
CC successive AMPylation events occur on Tyr-81.
CC {ECO:0000250|UniProtKB:A0A0B0QJR1}.
CC -!- SIMILARITY: Belongs to the HepT RNase toxin family. {ECO:0000305}.
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DR EMBL; AE008691; AAM24012.1; -; Genomic_DNA.
DR RefSeq; WP_011025150.1; NC_003869.1.
DR AlphaFoldDB; Q8RBR1; -.
DR SMR; Q8RBR1; -.
DR STRING; 273068.TTE0752; -.
DR EnsemblBacteria; AAM24012; AAM24012; TTE0752.
DR KEGG; tte:TTE0752; -.
DR eggNOG; COG2361; Bacteria.
DR HOGENOM; CLU_142825_3_3_9; -.
DR OMA; MRRDELY; -.
DR OrthoDB; 1967941at2; -.
DR Proteomes; UP000000555; Chromosome.
DR GO; GO:0110001; C:toxin-antitoxin complex; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR Gene3D; 1.20.120.580; -; 1.
DR InterPro; IPR008201; HepT-like.
DR InterPro; IPR037038; HepT-like_sf.
DR Pfam; PF01934; DUF86; 1.
PE 3: Inferred from homology;
KW Hydrolase; Nuclease; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..112
FT /note="Putative RNase TTE0752"
FT /id="PRO_0000158261"
FT MOTIF 74..81
FT /note="RX(4)HXY motif"
FT /evidence="ECO:0000250|UniProtKB:A0A0B0QJR1"
FT ACT_SITE 74
FT /evidence="ECO:0000250|UniProtKB:A0A0B0QJR1"
FT ACT_SITE 79
FT /evidence="ECO:0000250|UniProtKB:A0A0B0QJR1"
FT MOD_RES 81
FT /note="O-di-AMP-tyrosine"
FT /evidence="ECO:0000250|UniProtKB:A0A0B0QJR1"
SQ SEQUENCE 112 AA; 13452 MW; 1BF8F4EBAB0CB084 CRC64;
MKTPRPYLEH ILQECEFLIE RVKGISFEDF VKDPVLTRAF VRSLEIIGEA VKNLPKEFRE
KHSKVPWKEI AGMRDKLIHE YFGVNYRIIW ETILKEIPEL EKQVKEILQK EK
