ID   Y752_MYCBO              Reviewed;         318 AA.
AC   O53795; A0A1R3XW85; Q79BH8; X2BFU1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Mb0752c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=BQ2027_MB0752C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Pasteur;
RA   Kim J.K., Choe Y.K.;
RT   "Cloning and sequencing of Mycobacterium bovis BCG gene cluster containing
RT   secY gene.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; U77912; AAD09882.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIT99351.1; -; Genomic_DNA.
DR   PIR; F70822; F70822.
DR   RefSeq; NP_854410.1; NC_002945.3.
DR   RefSeq; WP_003403717.1; NC_002945.4.
DR   AlphaFoldDB; O53795; -.
DR   SMR; O53795; -.
DR   EnsemblBacteria; SIT99351; SIT99351; BQ2027_MB0752C.
DR   PATRIC; fig|233413.5.peg.819; -.
DR   OMA; NAFNWEE; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..318
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Mb0752c"
FT                   /id="PRO_0000361139"
FT   BINDING         135
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         164..165
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   318 AA;  34950 MW;  F25150B40E9D1BE5 CRC64;
     MTQTGSARFE GDSWDLASSV GLTATMVAAA RAVAGRAPGA LVNDQFAEPL VRAVGVDFFV
     RMASGELDPD ELAEDEANGL RRFADAMAIR THYFDNFFLD ATRAGIRQAV ILASGLDSRA
     YRLRWPAGTI VFEVDQPQVI DFKTTTLAGL GAAPTTDRRT VAVDLRDDWP TALQKAGFDN
     AQRTAWIAEG LLGYLSAEAQ DRLLDQITAQ SVPGSQFATE VLRDINRLNE EELRGRMRRL
     AERFRRHGLD LDMSGLVYFG DRTDARTYLA DHGWRTASAS TTDLLAEHGL PPIDGDDAPF
     GEVIYVSAEL KQKHQDTR