Y756_MYCTU
ID Y756_MYCTU Reviewed; 318 AA.
AC P9WFI5; L0T4P9; Q7ARS3; Q7D9D6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0731c;
DE EC=2.1.1.-;
GN OrderedLocusNames=Rv0731c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP SEQUENCE REVISION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12368430; DOI=10.1099/00221287-148-10-2967;
RA Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT H37Rv.";
RL Microbiology 148:2967-2973(2002).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR EMBL; AL123456; CCP43476.1; -; Genomic_DNA.
DR RefSeq; NP_215245.1; NC_000962.3.
DR RefSeq; WP_003403717.1; NZ_NVQJ01000007.1.
DR PDB; 6ID6; X-ray; 1.63 A; A=11-311.
DR PDBsum; 6ID6; -.
DR AlphaFoldDB; P9WFI5; -.
DR SMR; P9WFI5; -.
DR STRING; 83332.Rv0731c; -.
DR PaxDb; P9WFI5; -.
DR DNASU; 888556; -.
DR GeneID; 888556; -.
DR KEGG; mtu:Rv0731c; -.
DR TubercuList; Rv0731c; -.
DR eggNOG; COG3315; Bacteria.
DR OMA; NAFNWEE; -.
DR PhylomeDB; P9WFI5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR011610; CHP00027_methylltransferase.
DR InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF04072; LCM; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..318
FT /note="Putative S-adenosyl-L-methionine-dependent
FT methyltransferase Rv0731c"
FT /id="PRO_0000361243"
FT BINDING 135
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 164..165
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT HELIX 16..19
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 22..35
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 47..54
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 57..64
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 69..71
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 74..103
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 108..112
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 119..122
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 130..135
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 137..149
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 155..162
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 169..175
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 185..188
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 192..194
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 197..209
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 216..222
FT /evidence="ECO:0007829|PDB:6ID6"
FT TURN 227..229
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 230..246
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 253..255
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 265..271
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 274..280
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 281..287
FT /evidence="ECO:0007829|PDB:6ID6"
FT HELIX 295..297
FT /evidence="ECO:0007829|PDB:6ID6"
FT STRAND 303..310
FT /evidence="ECO:0007829|PDB:6ID6"
SQ SEQUENCE 318 AA; 34950 MW; F25150B40E9D1BE5 CRC64;
MTQTGSARFE GDSWDLASSV GLTATMVAAA RAVAGRAPGA LVNDQFAEPL VRAVGVDFFV
RMASGELDPD ELAEDEANGL RRFADAMAIR THYFDNFFLD ATRAGIRQAV ILASGLDSRA
YRLRWPAGTI VFEVDQPQVI DFKTTTLAGL GAAPTTDRRT VAVDLRDDWP TALQKAGFDN
AQRTAWIAEG LLGYLSAEAQ DRLLDQITAQ SVPGSQFATE VLRDINRLNE EELRGRMRRL
AERFRRHGLD LDMSGLVYFG DRTDARTYLA DHGWRTASAS TTDLLAEHGL PPIDGDDAPF
GEVIYVSAEL KQKHQDTR
