Y7588_DICDI
ID Y7588_DICDI Reviewed; 719 AA.
AC Q55GN6;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Probable phosphatidylinositol phosphate kinase DDB_G0267588;
DE EC=2.7.1.-;
GN ORFNames=DDB_G0267588;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP FUNCTION, AND PHOSPHORYLATION AT THR-262.
RX PubMed=18635356; DOI=10.1016/j.cub.2008.06.068;
RA Kamimura Y., Xiong Y., Iglesias P.A., Hoeller O., Bolourani P.,
RA Devreotes P.N.;
RT "PIP3-independent activation of TorC2 and PKB at the cell's leading edge
RT mediates chemotaxis.";
RL Curr. Biol. 18:1034-1043(2008).
CC -!- FUNCTION: May be involved in signaling events that underlie chemotaxis
CC via the chemoattractant-mediated pkgB phosphorylation.
CC {ECO:0000269|PubMed:18635356}.
CC -!- PTM: Phosphorylated at Thr-262 by pkgB. {ECO:0000305|PubMed:18635356}.
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DR EMBL; AAFI02000003; EAL73247.1; -; Genomic_DNA.
DR RefSeq; XP_647148.1; XM_642056.1.
DR AlphaFoldDB; Q55GN6; -.
DR SMR; Q55GN6; -.
DR STRING; 44689.DDB0234212; -.
DR iPTMnet; Q55GN6; -.
DR PaxDb; Q55GN6; -.
DR EnsemblProtists; EAL73247; EAL73247; DDB_G0267588.
DR GeneID; 8615951; -.
DR KEGG; ddi:DDB_G0267588; -.
DR dictyBase; DDB_G0267588; pikI.
DR eggNOG; KOG0229; Eukaryota.
DR HOGENOM; CLU_384720_0_0_1; -.
DR InParanoid; Q55GN6; -.
DR OMA; SHDMKFI; -.
DR PhylomeDB; Q55GN6; -.
DR Reactome; R-DDI-1660499; Synthesis of PIPs at the plasma membrane.
DR Reactome; R-DDI-6811555; PI5P Regulates TP53 Acetylation.
DR Reactome; R-DDI-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-DDI-8847453; Synthesis of PIPs in the nucleus.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q55GN6; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016307; F:phosphatidylinositol phosphate kinase activity; ISS:dictyBase.
DR GO; GO:1902635; P:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; IMP:dictyBase.
DR GO; GO:0032147; P:activation of protein kinase activity; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IMP:dictyBase.
DR Gene3D; 3.30.800.10; -; 1.
DR InterPro; IPR023610; PInositol-4-P-5-kinase.
DR InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR PANTHER; PTHR23086; PTHR23086; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00330; PIPKc; 1.
DR PROSITE; PS51455; PIPK; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Transferase.
FT CHAIN 1..719
FT /note="Probable phosphatidylinositol phosphate kinase
FT DDB_G0267588"
FT /id="PRO_0000393332"
FT DOMAIN 316..718
FT /note="PIPK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT REGION 47..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 262
FT /note="Phosphothreonine"
FT /evidence="ECO:0000305|PubMed:18635356"
SQ SEQUENCE 719 AA; 80506 MW; 51241851614B7B0E CRC64;
MNTIDTVVPE MNPALSESIV FAPIRTGEEG EKIPIIPINA ALSESIVFSP IPPPPSTTDN
TTNTTTTTIE TTATDNTNDT EEKQENIENN NNNNNSSISS PNSIDGANKK DSIELEEDKE
HSIKRKDGSL GDVVDNEKII PNSLDSDAPE ETSNLNKKSE INIKQVLKNP SFDATNDNHN
PQEVDNTDNP DKPTTPRQTT TTTTTTTTTT STNSTSNKLP NNGDNTVSFD EKFDPNVSHS
NLNDDYKASG SSDSPNRVRL NTSQRLKMYK QKSEKRLSHR PKSIKLEHKK NVLGEIIYKG
HPSWALMLNI QTGIRNAVGK SMGTEGGVNA KTPQQYHTLR KPSEFKRKED FYVSPKTQRF
ESAGTAMTNA HSTGAFKFKD YCPNAFRYLR YLFGIDTADF MVSLCNTLKN GENALRELPT
PGKSGSLFFF SHDMKFIIKT IPKDEAKLLR DILPSYLEHI QSNPNSLLPR FFGLYRVKPH
SGRQVRFVIM GNLFPTKKKI HERYDLKGSV VGREASVDEK KSDSVTFKDI DFRNRKQKIF
LGPGKKQSFI DQIKRDCKLL QSLNIMDYSL LIGIHYPHRE NEPPSPSLLR STLEDSSDFE
SPSMEQSSAG QQQQQRGSGN YDNSGAGRDS TTGGAAPKEN DEIYISAFQQ DEGGIKSQGG
DTEEHYFLGI IDILMLYSLR KKVEHTYKTL KFGAKQEISS VSPDEYSERF QEFLSTIIE
