ID   Y760_STAA8              Reviewed;         356 AA.
AC   Q2G061;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Uncharacterized membrane protein SAOUHSC_00760;
GN   OrderedLocusNames=SAOUHSC_00760;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CP000253; ABD29892.1; -; Genomic_DNA.
DR   RefSeq; WP_000460983.1; NZ_LS483365.1.
DR   RefSeq; YP_499319.1; NC_007795.1.
DR   AlphaFoldDB; Q2G061; -.
DR   SMR; Q2G061; -.
DR   STRING; 1280.SAXN108_0813; -.
DR   EnsemblBacteria; ABD29892; ABD29892; SAOUHSC_00760.
DR   GeneID; 3919521; -.
DR   KEGG; sao:SAOUHSC_00760; -.
DR   PATRIC; fig|93061.5.peg.686; -.
DR   eggNOG; COG2199; Bacteria.
DR   HOGENOM; CLU_000445_11_1_9; -.
DR   OMA; HGAWKDL; -.
DR   PRO; PR:Q2G061; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0052621; F:diguanylate cyclase activity; IBA:GO_Central.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:InterPro.
DR   GO; GO:1902201; P:negative regulation of bacterial-type flagellum-dependent cell motility; IBA:GO_Central.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR011620; Sig_transdc_His_kinase_LytS_TM.
DR   Pfam; PF07694; 5TM-5TMR_LYT; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   TIGRFAMs; TIGR00254; GGDEF; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="Uncharacterized membrane protein SAOUHSC_00760"
FT                   /id="PRO_0000286959"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          218..353
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00095"
SQ   SEQUENCE   356 AA;  40345 MW;  E687E1CD5FFA8989 CRC64;
     MFEAFIYNIS VIVAGIYLFH RLQYSENKRM VFSKAYVTVL MTIVSLLLSV YPIPYREDYL
     IHLTFVPLLF LGRFTNMVYT LSATVIVAIV EIVVFNNSIM YGVTLIVIAA VTSAIGPFLK
     QNDVLSLLIL NVVTIIILFG VALVSPIYTL SEVIILIPIS LIITLASAIT FVDIWHFFSL
     VNRYENEDKY DYLTGLGNVK EFDRHLNEIS RKAEKEHQSI ALLLIDIDGF KDVNDTYSHK
     SGDAVLKQMS QLLKNYVPNQ FKIFRNGGEE FSVVIHNYSL DQSVKLAENI RSGVEKSSFH
     LPNKEVIKLS VSIGVGYLTD DDPKSQRKVF KDADDMVHVA KNQGRNKVMF NPIINL