ID   Y769_MYCTU              Reviewed;         248 AA.
AC   P9WGQ9; L0T4U6; P71824; Q7D9B1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized oxidoreductase Rv0769;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0769;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43516.1; -; Genomic_DNA.
DR   PIR; D70707; D70707.
DR   RefSeq; NP_215283.1; NC_000962.3.
DR   RefSeq; WP_003898579.1; NZ_NVQJ01000035.1.
DR   AlphaFoldDB; P9WGQ9; -.
DR   SMR; P9WGQ9; -.
DR   STRING; 83332.Rv0769; -.
DR   PaxDb; P9WGQ9; -.
DR   DNASU; 888837; -.
DR   GeneID; 888837; -.
DR   KEGG; mtu:Rv0769; -.
DR   TubercuList; Rv0769; -.
DR   eggNOG; COG1028; Bacteria.
DR   OMA; QHGKIDN; -.
DR   PhylomeDB; P9WGQ9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Uncharacterized oxidoreductase Rv0769"
FT                   /id="PRO_0000415505"
FT   ACT_SITE        153
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         8..32
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         143
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   248 AA;  25966 MW;  2F62C15EEBF4A949 CRC64;
     MFDSKVAIVT GAAQGIGQAY AQALAREGAS VVVADINADG AAAVAKQIVA DGGTAIHVPV
     DVSDEDSAKA MVDRAVGAFG GIDYLVNNAA IYGGMKLDLL LTVPLDYYKK FMSVNHDGVL
     VCTRAVYKHM AKRGGGAIVN QSSTAAWLYS NFYGLAKVGV NGLTQQLARE LGGMKIRINA
     IAPGPIDTEA TRTVTPAELV KNMVQTIPLS RMGTPEDLVG MCLFLLSDSA SWITGQIFNV
     DGGQIIRS