ID   Y770_MYCTO              Reviewed;         295 AA.
AC   P9WNY2; L0T7N9; P71825;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Uncharacterized oxidoreductase MT0794;
DE            EC=1.1.-.-;
GN   OrderedLocusNames=MT0794;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the HIBADH-related family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45036.1; -; Genomic_DNA.
DR   PIR; E70707; E70707.
DR   RefSeq; WP_003403924.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNY2; -.
DR   SMR; P9WNY2; -.
DR   EnsemblBacteria; AAK45036; AAK45036; MT0794.
DR   KEGG; mtc:MT0794; -.
DR   PATRIC; fig|83331.31.peg.853; -.
DR   HOGENOM; CLU_035117_1_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..295
FT                   /note="Uncharacterized oxidoreductase MT0794"
FT                   /id="PRO_0000427047"
FT   ACT_SITE        176
FT                   /evidence="ECO:0000250"
FT   BINDING         11..25
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         252
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   295 AA;  30446 MW;  7A9E7FBFAD0E95B8 CRC64;
     MTAHPETPRL GYIGLGNQGA PMAKRLLDWP GGLTVFDVRV EAMAPFVEGG ATAAASVSDV
     AEADIISITV FDDAQVSSVI TADNGLATHA KPGTIVAIHS TIADTTAVDL AEKLKPQGIH
     IVDAPVSGGA AAAAKGELAV MVGADDEAFQ RIKEPFSRWA SLLIHAGEPG AGTRMKLARN
     MLTFVSYAAA AEAQRLAEAC GLDLVALGKV VRHSDSFTGG AGAIMFRNTT APMEPADPLR
     PLLEHTRGLG EKDLSLALAL GEVVSVDLPL AQLALQRLAA GLGVPHPDTE PAKET