ID   Y770_MYCTU              Reviewed;         295 AA.
AC   P9WNY3; L0T7N9; P71825;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Uncharacterized oxidoreductase Rv0770;
DE            EC=1.1.-.-;
GN   OrderedLocusNames=Rv0770; ORFNames=MTCY369.15;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the HIBADH-related family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43517.1; -; Genomic_DNA.
DR   PIR; E70707; E70707.
DR   RefSeq; NP_215284.1; NC_000962.3.
DR   RefSeq; WP_003403924.1; NZ_NVQJ01000035.1.
DR   AlphaFoldDB; P9WNY3; -.
DR   SMR; P9WNY3; -.
DR   STRING; 83332.Rv0770; -.
DR   PaxDb; P9WNY3; -.
DR   PRIDE; P9WNY3; -.
DR   DNASU; 888868; -.
DR   GeneID; 888868; -.
DR   KEGG; mtu:Rv0770; -.
DR   TubercuList; Rv0770; -.
DR   eggNOG; COG2084; Bacteria.
DR   OMA; QMFMQAS; -.
DR   PhylomeDB; P9WNY3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   1: Evidence at protein level;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Uncharacterized oxidoreductase Rv0770"
FT                   /id="PRO_0000173069"
FT   ACT_SITE        176
FT                   /evidence="ECO:0000250"
FT   BINDING         11..25
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         252
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   295 AA;  30446 MW;  7A9E7FBFAD0E95B8 CRC64;
     MTAHPETPRL GYIGLGNQGA PMAKRLLDWP GGLTVFDVRV EAMAPFVEGG ATAAASVSDV
     AEADIISITV FDDAQVSSVI TADNGLATHA KPGTIVAIHS TIADTTAVDL AEKLKPQGIH
     IVDAPVSGGA AAAAKGELAV MVGADDEAFQ RIKEPFSRWA SLLIHAGEPG AGTRMKLARN
     MLTFVSYAAA AEAQRLAEAC GLDLVALGKV VRHSDSFTGG AGAIMFRNTT APMEPADPLR
     PLLEHTRGLG EKDLSLALAL GEVVSVDLPL AQLALQRLAA GLGVPHPDTE PAKET