ID   Y7744_DICDI             Reviewed;         429 AA.
AC   Q55GA8;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0267744;
GN   ORFNames=DDB_G0267744;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73325.1; -; Genomic_DNA.
DR   RefSeq; XP_647276.1; XM_642184.1.
DR   AlphaFoldDB; Q55GA8; -.
DR   SMR; Q55GA8; -.
DR   STRING; 44689.DDB0189514; -.
DR   PaxDb; Q55GA8; -.
DR   PRIDE; Q55GA8; -.
DR   EnsemblProtists; EAL73325; EAL73325; DDB_G0267744.
DR   GeneID; 8616083; -.
DR   KEGG; ddi:DDB_G0267744; -.
DR   dictyBase; DDB_G0267744; -.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q55GA8; -.
DR   OMA; PCPNGCK; -.
DR   PhylomeDB; Q55GA8; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q55GA8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..429
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0267744"
FT                   /id="PRO_0000393756"
FT   ZN_FING         22..60
FT                   /note="RING-type; degenerate"
FT   ZN_FING         151..203
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         204..265
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
SQ   SEQUENCE   429 AA;  50098 MW;  7F3DC5FAB70DA0C4 CRC64;
     MEISDILFDD LVVGEINDDF ICVICSHLQV DIYQCVEGHF ACKNCFLKMI ELKKQCMTCR
     CEIKSIESLS KNRYLEKEVR KLNIYCPNSF SDLKNSIKDE NACKDIITIE GLETHLKNCK
     FTLKECPNNK NCNDDNKNKE CLKIRQGEFD HHLKECPNSL IKCEHCSIEI TRSKQTDHIE
     NHCLKVLKQC EFCFKLIERG EFNNHQDTIC LSKLIKCPFN EGGCVDLVKR SDIKEHLSVL
     AGEHLLYSIT MINSLSLKLE KSNSELQESI SYSRLLKKDF KELKKSKSYS GRWVIEKWSE
     KLKQYGKGQS IQFQKFNTST SPSSAFSYFT LRLFPNGQYN GETISIHLVK LFRNKSRISF
     SFEIENHINP SSNEEIDSRF LFGNLNDYYS TIFYKEYNKE NGFISEDDTL VIHFNVEILK
     YYDDTFITK