ID   Y7754_DICDI             Reviewed;         462 AA.
AC   Q55GA0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0267754;
GN   ORFNames=DDB_G0267754;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000003; EAL73330.1; -; Genomic_DNA.
DR   RefSeq; XP_647284.1; XM_642192.1.
DR   AlphaFoldDB; Q55GA0; -.
DR   SMR; Q55GA0; -.
DR   STRING; 44689.DDB0189521; -.
DR   PaxDb; Q55GA0; -.
DR   PRIDE; Q55GA0; -.
DR   EnsemblProtists; EAL73330; EAL73330; DDB_G0267754.
DR   GeneID; 8616090; -.
DR   KEGG; ddi:DDB_G0267754; -.
DR   dictyBase; DDB_G0267754; -.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q55GA0; -.
DR   OMA; DSWSLQF; -.
DR   PhylomeDB; Q55GA0; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q55GA0; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 4.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..462
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0267754"
FT                   /id="PRO_0000393758"
FT   DOMAIN          326..449
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         24..62
FT                   /note="RING-type; degenerate"
FT   ZN_FING         150..217
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         214..273
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   REGION          104..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  53475 MW;  D7F9DE76C9A5782A CRC64;
     MTSLISITLD ELLINEDIND DYTCCVCECL LIEALQCRNG HVACKNCFIK IVKSKKECMT
     CRCEIKSIES LSKNRYLEKE IRKLNINCPN SFLKRELNLN NNNKNGNGNE GSSANEIEQP
     QQPQQQQPQE LIKDINNGCK EILTIDQLDS HLKQCEYRFL KCTNLYANDL CSELDICGYD
     YRYNQSEKHR DECPYGIIGC TLCGKDCSRV DIESHTENHC PKLLVKCPTC NQDQLIARCD
     LDDHLSVDCA MIEIDCILKE SGCKERVKRN QLANHLSSDN HLLFINNQFN QQNDIINQLK
     LELSHCNDLN EILTAKLDRY NNDNTMFRGK WVISNWTDKL NQYPPKKYLS LDFNLSQNKP
     FSIRVYPNGS SVMWHNCTIS LVKLYQTEST IKFSFEIENE DPLKNDLQTK TDIFKGLNDS
     WSLQFFKVCD QANNNGFIIN DTLTINFSIK IKKCFENIFI TE