Y777_STRP3
ID Y777_STRP3 Reviewed; 226 AA.
AC P0DH28; Q878S2; Q8K7J5;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 46.
DE RecName: Full=UPF0758 protein SpyM3_0777;
GN OrderedLocusNames=SpyM3_0777;
OS Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=198466;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-595 / MGAS315;
RX PubMed=12122206; DOI=10.1073/pnas.152298499;
RA Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT encoded toxins, the high-virulence phenotype, and clone emergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC -!- SIMILARITY: Belongs to the UPF0758 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM79384.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014074; AAM79384.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_011106761.1; NC_004070.1.
DR AlphaFoldDB; P0DH28; -.
DR SMR; P0DH28; -.
DR EnsemblBacteria; AAM79384; AAM79384; SpyM3_0777.
DR KEGG; spg:SpyM3_0777; -.
DR HOGENOM; CLU_073529_0_2_9; -.
DR OMA; AMPDYEL; -.
DR Proteomes; UP000000564; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd08071; MPN_DUF2466; 1.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR025657; RadC_JAB.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001405; UPF0758.
DR InterPro; IPR020891; UPF0758_CS.
DR PANTHER; PTHR30471; PTHR30471; 1.
DR Pfam; PF04002; RadC; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR TIGRFAMs; TIGR00608; radc; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS01302; UPF0758; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Metalloprotease; Protease; Zinc.
FT CHAIN 1..226
FT /note="UPF0758 protein SpyM3_0777"
FT /id="PRO_0000190740"
FT DOMAIN 103..225
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT MOTIF 174..187
FT /note="JAMM motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 174
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 176
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 187
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 226 AA; 25787 MW; 3B4F10EE60CE6139 CRC64;
MYSIKCDDNK VMPRERLMRL GAESLSNQEL LAILLRTGNK EKHVLELSSY LLSHLDSLAD
FKKMSLQELQ HLAGIGKVKA IEIKAMIELV SRILATDKTL TDSVLTSVQV AEKIMAALGD
KKQEHLVVLY LDNQNRIFEE KTIFIGTVRR SLAEPREILY YACKNMATSL IVIHNHPSGN
IEPSSNDYCF TEKIKRSCED LGIICLDHII VSYKDYYSFR EKSTLF