ID   Y7813_DICDI             Reviewed;         477 AA.
AC   Q54YP8;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0278133;
GN   ORFNames=DDB_G0278133;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68239.1; -; Genomic_DNA.
DR   RefSeq; XP_642154.1; XM_637062.1.
DR   AlphaFoldDB; Q54YP8; -.
DR   PaxDb; Q54YP8; -.
DR   EnsemblProtists; EAL68239; EAL68239; DDB_G0278133.
DR   GeneID; 8621361; -.
DR   KEGG; ddi:DDB_G0278133; -.
DR   dictyBase; DDB_G0278133; -.
DR   eggNOG; ENOG502RBHI; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54YP8; -.
DR   OMA; HIENCEY; -.
DR   PhylomeDB; Q54YP8; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54YP8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..477
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0278133"
FT                   /id="PRO_0000393767"
FT   DOMAIN          331..463
FT                   /note="MATH"
FT   ZN_FING         45..88
FT                   /note="RING-type; degenerate"
FT   ZN_FING         160..211
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         212..267
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          271..326
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   477 AA;  55551 MW;  BBD1E06ECEE7F61D CRC64;
     MLDFINLINN INNPTSPTKI TPKVIPIKYE IKDILVDSDE EKYECDICTL ELFIESEPKA
     LQCKEGHLAC RRCWERYLST NKQCMTCKTP ISSISELSRN RYLEKEYSNW LNDRLVFCPN
     SNENVFRLNM SGLPAINNSN QTLHQDLCNH GAMKFSELQN HYKACESRIL QCNLCLIKFC
     SKDSDKHQNE CSKVYSKCEF CNSNILRSSL SDHHKTHCTK YLIECPHCKI MIKRDTITKH
     INDDCEEIMI TCSEYLCGKR FTRSKMQIHS LEHSVTKLMN QNEIIKKDNQ NLDQEKKIEE
     IKLKLNNLLN NYIQLKNEIA VLKQNSFKEM VYSNKWIIPE YRSFNALYTH KKSKNSNDFQ
     VGSHTFYIKI YPNGQAGKQG KFGVFLERKP RYGILLKYMF SFSLLPPEDS TATKVSLGPI
     HRVLILLLID FEESRSLSCG TNVFTDSRKV LKDFLNEKGE LEISFSITIQ DEKIIPL