Y7875_DICDI
ID Y7875_DICDI Reviewed; 1211 AA.
AC Q1ZXE2;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=PH domain-containing protein DDB_G0287875;
GN ORFNames=DDB_G0287875;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- INDUCTION: Down-regulated by phagocytosis and growth on bacteria.
CC {ECO:0000269|PubMed:18559084}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000104; EAS66845.1; -; Genomic_DNA.
DR RefSeq; XP_001134528.1; XM_001134528.1.
DR AlphaFoldDB; Q1ZXE2; -.
DR SMR; Q1ZXE2; -.
DR STRING; 44689.DDB0232240; -.
DR PaxDb; Q1ZXE2; -.
DR EnsemblProtists; EAS66845; EAS66845; DDB_G0287875.
DR GeneID; 8626273; -.
DR KEGG; ddi:DDB_G0287875; -.
DR dictyBase; DDB_G0287875; dydA.
DR eggNOG; KOG0035; Eukaryota.
DR HOGENOM; CLU_269760_0_0_1; -.
DR InParanoid; Q1ZXE2; -.
DR OMA; SNSERHT; -.
DR PRO; PR:Q1ZXE2; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IMP:dictyBase.
DR GO; GO:0043520; P:regulation of myosin II filament assembly; IMP:dictyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1211
FT /note="PH domain-containing protein DDB_G0287875"
FT /id="PRO_0000385366"
FT DOMAIN 5..90
FT /note="Ras-associating 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT DOMAIN 132..223
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 277..384
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 392..502
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1112..1196
FT /note="Ras-associating 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT REGION 103..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 527..572
FT /evidence="ECO:0000255"
FT COILED 703..847
FT /evidence="ECO:0000255"
FT COILED 880..909
FT /evidence="ECO:0000255"
FT COILED 1048..1076
FT /evidence="ECO:0000255"
FT COMPBIAS 527..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 137178 MW; 124C34A8EF2436AD CRC64;
MEPPQKKILK VFDQDGLYKT MVIEPSSTTG EICEKFAKKL FLEDSEVVQF SLFIFEGGVR
HQLKNTDFPF DYLIKYEKKD YKFFFLNPNG EFISFDKDKQ VKKSQSASTS GSAPPKKEPP
KPQELQQKQH ISKGKSGWLL RKRPGRYDKL YSVSKADKYL RLYENEDTDN DPLYELSLEN
SIIELKQDLH LQLTLGNSER YIFTHESESE IVSWAQELQA TMNYTPGSSS SGSKTNIIKN
SSPMGGMLMG GGGGGGGYIP STKDLGVKLQ SKAENTTTLV STLIQWVNHI LEGKGIKVEE
TEVLSAFSDG IVFINLIEDL FNQTISYRKG KSVYEMQSNI DKCLDVLKTK CGCDYGKILS
SDVSECKVAK IIVRILWSMF VGYFCNCEGK EFNMRDKLIS WCSTIVLQES SKQIIVESPS
SLRNPMVFAV LVNKFAGSTT LDFNALQKIK SKQDQAQQII EAAFNYLSIP MVVDSSFWND
DQLDEKSFLI YLSFYYIYLS GQEEEKSKFL QSCINPRPSV EPEQTISIRD KQLKLMREKK
EEEDRLKKEK EEKEKEEKEK LEKESSAAAA ATSSIASTAN SNSTEPPKPT TVPLKKTISK
LPPRKLPPTV SSPTTTTTTT VPTTVPTTVT TTTTTTSPTT SPTLTPKQPI GTTIKKPATA
PLKLKPVAKP LPQPTPSSST STTTTPTTTP SSPKPTPVPR TPQLEKEKQD RLEKARLEKE
KAEKEEQEFL KQQQEEEEEE QRLLLEQQKQ QQEGQERLRK EEEEQQQQRE LEEKQRQIDE
EEAEEEARIR ELEEEARKSK ERLEKARLDK LAKAQKERED KEREEKEKKE KEERERKERK
HDENDMDTFK LLEDIVSSSS SPTITPPQSL HSSQIIRTTI EEDDQTNSEL EMFQNEYNRL
QDEEEHINSF LKLGSSGSNN SNNNNNNNNN KSGASSVTES VTTNKHKSID ILSDNSSVLS
SLDDIINSID KKTSATTSDS FNLSTSSTSL SFLPSSPDLS TNSTFTTNNN NDDETKARSL
TSKARKPLPT LTKEQQSIID KQTGLVSKQS TNNESNEQQQ QQQQQQQLQQ QQSSQNSTTS
ISTVNPSNLS INNEEKEKES EPHKPPPKNT QGRVVVRICL EGFGDVLFCS FAIGYDTLCG
TVRDMVIKKM KVSSTEEFEY SLHIVRDGLE RVLDDDEILL EAEDKIDRFV FKKNDIDRRL
LISNHRPVSS K
