ID   Y788_STRMU              Reviewed;         451 AA.
AC   Q8DUV4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Uncharacterized RNA methyltransferase SMU_788;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SMU_788;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01024}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014133; AAN58507.1; -; Genomic_DNA.
DR   RefSeq; NP_721201.1; NC_004350.2.
DR   RefSeq; WP_002261942.1; NC_004350.2.
DR   AlphaFoldDB; Q8DUV4; -.
DR   SMR; Q8DUV4; -.
DR   STRING; 210007.SMU_788; -.
DR   PRIDE; Q8DUV4; -.
DR   EnsemblBacteria; AAN58507; AAN58507; SMU_788.
DR   KEGG; smu:SMU_788; -.
DR   PATRIC; fig|210007.7.peg.698; -.
DR   eggNOG; COG2265; Bacteria.
DR   HOGENOM; CLU_014689_7_0_9; -.
DR   OMA; FYAGDMK; -.
DR   PhylomeDB; Q8DUV4; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR030390; MeTrfase_TrmA_AS.
DR   InterPro; IPR030391; MeTrfase_TrmA_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   PANTHER; PTHR11061; PTHR11061; 1.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
DR   PROSITE; PS01231; TRMA_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..451
FT                   /note="Uncharacterized RNA methyltransferase SMU_788"
FT                   /id="PRO_0000162029"
FT   DOMAIN          1..59
FT                   /note="TRAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00208"
FT   ACT_SITE        408
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         283
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         312
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         333
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
FT   BINDING         381
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01024"
SQ   SEQUENCE   451 AA;  50838 MW;  B0590A197CD33EBE CRC64;
     MLKKNDIVEV EISDLSHDGA GIAKVDGLVF FVDNALPTEK IRMRVLKVKK NIAFGKVESY
     LAKSAYRSDN LTVDYLRTGI ADLGHLTYGQ QLNFKRKQVI NSLSKIAGIS DIEVADTLGM
     DNPTAYRNKA QVPVRRVNGQ LETGFFRKNS HALMPIEDYY IQDKEIDRLI NFTRDLLRRF
     DLKPYDEKEQ TGLIRNLVVR RGHYTGQIML VLVTTRSKIF RIEQMIEKII SEFPAVKSII
     QNINDRNTNA IFGSEFRTLY GEDTIEDTML GNRYIISAQS FYQVNTVMAE KLYQTAIDFS
     DLTPDDTVID AYSGIGTIGL SFAKKVKDVY GVEVIEAAVR DAEKNAALNN ITNVHYVADS
     AEKAMASWSK RGIKPDVILV DPPRKGLTES FIEASTAMQP RKITYISCAP ATMARDVKLY
     EELGYKLVKV QPVDLFPQTH HVECVALLVK A