ID   CASPC_CANLF             Reviewed;         386 AA.
AC   Q075B4; Q075B3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Caspase-12;
DE            Short=CASP-12;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Eckhart L., Uthman A., Sipos W., Tschachler E.;
RT   "Identification of dog caspase-12.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the activation cascade of caspases responsible
CC       for apoptosis execution. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer that consists of two anti-parallel arranged
CC       heterodimers, each one formed by two subunits (Potential). May interact
CC       with TRAF2 (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=B;
CC         IsoId=Q075B4-1; Sequence=Displayed;
CC       Name=2; Synonyms=A;
CC         IsoId=Q075B4-2; Sequence=VSP_030952;
CC   -!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
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DR   EMBL; DQ228670; ABB58696.1; -; mRNA.
DR   EMBL; DQ228671; ABB58697.1; -; mRNA.
DR   RefSeq; NP_001070704.1; NM_001077236.1. [Q075B4-2]
DR   AlphaFoldDB; Q075B4; -.
DR   SMR; Q075B4; -.
DR   STRING; 9612.ENSCAFP00000038116; -.
DR   PaxDb; Q075B4; -.
DR   PRIDE; Q075B4; -.
DR   Ensembl; ENSCAFT00030017947; ENSCAFP00030015674; ENSCAFG00030009693. [Q075B4-2]
DR   Ensembl; ENSCAFT00040027945; ENSCAFP00040024266; ENSCAFG00040015183. [Q075B4-2]
DR   Ensembl; ENSCAFT00845000843; ENSCAFP00845000634; ENSCAFG00845000482. [Q075B4-1]
DR   GeneID; 479458; -.
DR   KEGG; cfa:479458; -.
DR   CTD; 100506742; -.
DR   VEuPathDB; HostDB:ENSCAFG00845000482; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   GeneTree; ENSGT00940000162555; -.
DR   OrthoDB; 1327703at2759; -.
DR   Proteomes; UP000002254; Chromosome 5.
DR   Bgee; ENSCAFG00000014864; Expressed in retina and 45 other tissues.
DR   GO; GO:0097169; C:AIM2 inflammasome complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
DR   GO; GO:0072559; C:NLRP3 inflammasome complex; IBA:GO_Central.
DR   GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR   CDD; cd00032; CASc; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR035713; Caspase_12.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR002398; Pept_C14.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR10454; PTHR10454; 1.
DR   PANTHER; PTHR10454:SF134; PTHR10454:SF134; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; SSF52129; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Apoptosis; Hydrolase; Phosphoprotein; Protease;
KW   Reference proteome; Thiol protease; Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000317439"
FT   CHAIN           ?..386
FT                   /note="Caspase-12"
FT                   /id="PRO_0000317440"
FT   DOMAIN          1..91
FT                   /note="CARD"
FT   ACT_SITE        218
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        266
FT                   /evidence="ECO:0000250"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q920D5"
FT   VAR_SEQ         1
FT                   /note="M -> MAGKRQSQDPVNAIKVVASTMLNSFLEDLKEKNVLNKQELQTMGQTV
FT                   NVITKKTENLVGDLTEKTQVVGKIFKDHFLNSGSLLSLKSHAENEDECSESSS (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_030952"
SQ   SEQUENCE   386 AA;  44020 MW;  7B0E0625946F50C6 CRC64;
     MAGKRQSQDP VNAIKVVAST MLNSFLEDLK EKNVLNKQEL QTMGQTVNVI TKKTENLVGD
     LTEKTQVVGK IFKDHFLNSG SLLSLKSHAE NEDECSESSS AVLQEIQASQ VKVRKLCPCD
     HSHEPKITNV HEIYPVMEKE GRTRLALIIC NSEFDYLSKR QGSEIDILGM QDLLENLGYS
     VVVKENLSAL EMKTELKNFA ARQEHKFSDS TFLVFMSHGT LDGICGTKHR NEEPDILHDD
     TIFQIFNNRN CRSLKDKPKV IIMQACRGRG DGAVWVTDVG EASAWTCDQP LQCYIFNDAI
     EKTHVEKDFI AFKSSTPHNV SWRLNTDGSL FISHLIHYFR EFSCCHHLEE IFRKVQNSFE
     TPNTMIQMPT IERVSMTRYF YLFPGN