ID   Y78_MYCSE               Reviewed;         742 AA.
AC   L8FLZ2; A0A2U9PH81; B3GNJ0;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Uncharacterized protein D806_0078;
GN   ORFNames=0071R {ECO:0000303|PubMed:18554329},
GN   D806_000790 {ECO:0000312|EMBL:AWT51073.1}, D806_0078;
OS   Mycolicibacterium smegmatis (strain MKD8) (Mycobacterium smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1214915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=MKD8;
RX   PubMed=18554329; DOI=10.1111/j.1365-2958.2008.06299.x;
RA   Coros A., Callahan B., Battaglioli E., Derbyshire K.M.;
RT   "The specialized secretory apparatus ESX-1 is essential for DNA transfer in
RT   Mycobacterium smegmatis.";
RL   Mol. Microbiol. 69:794-808(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MKD8;
RX   PubMed=23618714; DOI=10.1128/genomea.00148-13;
RA   Gray T.A., Palumbo M.J., Derbyshire K.M.;
RT   "Draft genome sequence of MKD8, a conjugal recipient Mycobacterium
RT   smegmatis strain.";
RL   Genome Announc. 1:E0014813-E0014813(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MKD8;
RA   Derbyshire K., Gray T.A., Champion M.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the ESX-1 / type VII specialized secretion
CC       system (T7SS), which exports several proteins including EsxA and EsxB
CC       (Probable). Involved in DNA conjugation in the recipient strain
CC       (PubMed:18554329). {ECO:0000269|PubMed:18554329}.
CC   -!- DISRUPTION PHENOTYPE: Loss of DNA conjugation when disrupted in
CC       recipient strain; strain still secretes EsxB (PubMed:18554329).
CC       {ECO:0000269|PubMed:18554329}.
CC   -!- MISCELLANEOUS: In the well characterized mc(2)155 strain this gene is
CC       interrupted and its 5' end is replaced; the last third of the protein
CC       is nearly identical in both strains (from residue 468 on in this
CC       entry). {ECO:0000305}.
CC   -!- MISCELLANEOUS: DNA conjugation in M.smegmatis is unidirectional with
CC       distinct donor and recipient strains; mc(2)155 is a donor strain while
CC       MKD8 is a recipient strain. Mutations in a donor strain that alter DNA
CC       transfer do not always alter DNA transfer in a recipient strain.
CC       {ECO:0000305|PubMed:18554329}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AWT51073.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; EU711429; ACE06964.1; -; Genomic_DNA.
DR   EMBL; CP027541; AWT51073.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; L8FLZ2; -.
DR   EnsemblBacteria; AWT51073; AWT51073; D806_000790.
DR   PATRIC; fig|1214915.3.peg.83; -.
DR   HOGENOM; CLU_021845_0_0_11; -.
DR   Proteomes; UP000011200; Chromosome.
PE   4: Predicted;
FT   CHAIN           1..742
FT                   /note="Uncharacterized protein D806_0078"
FT                   /id="PRO_0000438359"
FT   REGION          167..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..221
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..399
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..448
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  76150 MW;  2F21BE13C6E3F3F0 CRC64;
     MVTIQPDASE YGGQTVTGAA WPNIDESVLA SAASDLEAVA NHLRDNVVPS AGRQKMKLAD
     SWEGKGADSA LDEANAIIGE HEQNEVEARE AAAKLRRMEF AVAVAKTLAN QTAEQVQNDC
     QRIMDEGQPS EGEDTRFERV ATRIREGYDD NVRMVAEVSH QLAADLGIVP PEPWGHPGSP
     ARTPQTPDQH PDGQLGTVDS GSSAPAPPPS LFAPPPPSRN ADRPSQLGTE VAAKAEPTPS
     LETVQSGSPV PPDPLVGGEA PARSNPPFAQ PHSDAPSTSG ASTPPAVGPA PAPTTGSGTM
     RPQAPAQALP PGHLDSLSPA TSNEISSNAV SPSAFGAKSG TPLEQFQKGL ADAAKTGGSP
     QTLSTAPSQP LGAPPTTQPL GAAPPTAGPA APPTTGGPPA PVAQAAGGPG GGAGPAPVAP
     PLSGGVPGGA VPLGPPPTPP PAAPVTTPPL ASGAPVAPTG AAAGAAGGGG AQVAPIPVSA
     ARAERDLAQR AVRRSGVDPM ETARRIAAAL NAPGMTNVED FKFFWVTGLT ADGKIVVANN
     YGIAYIPQQV HLPEQVYMAS ADESISPAER ASWVNEPIVA VQRWAEHNGR VLRAVIATED
     QLKNSDAGVH HEVLRPEDIP ENGKMAGRDR LQVIAPDVSS QLAKIGDADL VSVLPPAPAD
     SNPPEDRRKS LWDNVWKPLA SRSAKRGERH LTAFVAYAAH AQEHALYAAH TAALPDEQRQ
     AIREFIYWQH VGQLTADALA PA