ID   CASPC_MACMU             Reviewed;         421 AA.
AC   Q153Z0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Caspase-12;
DE            Short=CASP-12;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kulka M., Goswami B.B.;
RT   "Caspase 12 expression in FrhK4 cells.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the activation cascade of caspases responsible
CC       for apoptosis execution. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer that consists of two anti-parallel arranged
CC       heterodimers, each one formed by two subunits (Potential). May interact
CC       with TRAF2 (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
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DR   EMBL; DQ644576; ABG21363.1; -; mRNA.
DR   RefSeq; NP_001035896.1; NM_001042431.2.
DR   AlphaFoldDB; Q153Z0; -.
DR   SMR; Q153Z0; -.
DR   STRING; 9544.ENSMMUP00000021744; -.
DR   MEROPS; C14.013; -.
DR   GeneID; 724039; -.
DR   KEGG; mcc:724039; -.
DR   CTD; 100506742; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   OrthoDB; 1327703at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0097169; C:AIM2 inflammasome complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
DR   GO; GO:0072559; C:NLRP3 inflammasome complex; IBA:GO_Central.
DR   GO; GO:0097199; F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR   CDD; cd00032; CASc; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR035713; Caspase_12.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR002398; Pept_C14.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR10454; PTHR10454; 1.
DR   PANTHER; PTHR10454:SF134; PTHR10454:SF134; 1.
DR   Pfam; PF00619; CARD; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52129; SSF52129; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Hydrolase; Phosphoprotein; Protease; Reference proteome;
KW   Thiol protease; Zymogen.
FT   PROPEP          1..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000317442"
FT   CHAIN           ?..421
FT                   /note="Caspase-12"
FT                   /id="PRO_0000317443"
FT   DOMAIN          1..92
FT                   /note="CARD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT   REGION          88..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        252
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        300
FT                   /evidence="ECO:0000250"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q920D5"
SQ   SEQUENCE   421 AA;  47759 MW;  E3EC30D08A863F72 CRC64;
     MADKKPSKED PVNMVKLLTR NVLDGIFDDL MENNVLNTEE LRNLGKGLNF MVNNAGNLVD
     NITEKAQMVG KILKDRLLSH PKQLSLEYQH ESEDQESEES SASSSSSTES EEENEESKDE
     ERAASAHSMA VPPTAPLEIQ GAQPSGRLKL CPHAHFRELK TKRADEIYPV MEKEGRTRLA
     LIICSKEFHY LLNRNGSELD LLGMQDLLEN LGYSVVIEEN LTAQEMETAL RQFAARPEHQ
     SSDSTFLVFM SHGILNGICG TKHWDQEPDV LHDDTIFEIF NNRNCRSLRD KPKVIIMQAC
     RGSGAGIVWF TTDSGKASAD THGQLLQSSI CNDAVTKAHV EKDFIAFKSS TPHNVSWRHE
     MSGSVFISQI IYYFKEYSWS HHLEEIFRKV QRSFETPNVV TQLPTIERLS MTRYFYLFPG
     N