ID   Y7957_DICDI             Reviewed;         540 AA.
AC   Q54JM2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Putative actin-fragmin kinase DDB_G0287957;
GN   ORFNames=DDB_G0287957;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AFK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000106; EAL63459.1; -; Genomic_DNA.
DR   RefSeq; XP_636964.1; XM_631872.1.
DR   AlphaFoldDB; Q54JM2; -.
DR   STRING; 44689.DDB0233252; -.
DR   PaxDb; Q54JM2; -.
DR   EnsemblProtists; EAL63459; EAL63459; DDB_G0287957.
DR   GeneID; 8626384; -.
DR   KEGG; ddi:DDB_G0287957; -.
DR   dictyBase; DDB_G0287957; -.
DR   HOGENOM; CLU_504769_0_0_1; -.
DR   InParanoid; Q54JM2; -.
DR   PhylomeDB; Q54JM2; -.
DR   PRO; PR:Q54JM2; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   InterPro; IPR015275; Actin-fragmin_kin_cat_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR037469; Put_AFK.
DR   PANTHER; PTHR38737; PTHR38737; 2.
DR   Pfam; PF09192; Act-Frag_cataly; 2.
DR   SUPFAM; SSF56112; SSF56112; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..540
FT                   /note="Putative actin-fragmin kinase DDB_G0287957"
FT                   /id="PRO_0000367582"
FT   REGION          37..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..68
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   540 AA;  62283 MW;  76FE4262A091FF0A CRC64;
     MTFIIKKVKN IFSTKKINNK TNNNNFKNEN LNIKNEILNN NNNNNNNKNN NNNNNNNNNI
     ENNSKNENFN NFNKIHNSPI SSPNLSPSLN SIDSINLNKI IIQNIDNFET NGNILNTSSP
     SLNSSVAKNN FIISDIQDID WNNLVNIELL NNNINNNNNT NNNNNNNIII LVTFYNGYDD
     FNQVILKSSN TMVQDVYASV LQVILKYPVP EMRLIDSCEE EFNKMSINLL KQSKLQSEQL
     FNIIQTQIEK PFFLIMEYKN GGKFFSQLNH KEYFSSQKNG EKKLKQLGKL LSFDLICNIN
     NNICNFNYNN CNNNNNNNNN NNNNNNNNNN NNNNNNNINN CNNNNNNNIS LNNSNNNLNS
     IFNNNNFNIF SNIIFYEQPD KNGWYFGIIH SSILCLNSSS FTPGYRNTMD RIKLLLFSIF
     QNPTTESLQI YHFRKYLSNN CNINLPSSSV HWSTNIQNGI AKGIDELVNS LNYQVFASTK
     QIVNNMIFST TDQNNNNVII NNNNSFTWKK GIDLIYIPFL FDVLKEIIIE HSNYKNKSKK