CASP_HUMAN
ID CASP_HUMAN Reviewed; 678 AA.
AC Q13948; B3KWH3; B3KWH8; B4DZZ2; G3V1Z6; J3KPQ6; Q53GU9; Q8TBS3;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Protein CASP;
GN Name=CUX1; Synonyms=CUTL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Umbilical vein;
RX PubMed=9332351; DOI=10.1016/s0378-1119(97)00243-6;
RA Lievens P.M.-J., Tufarelli C., Donady J.J., Stagg A., Neufeld E.J.;
RT "CASP, a novel, highly conserved alternative-splicing product of the
RT CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and
RT interacts with full-length CDP in vitro.";
RL Gene 197:73-81(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 9 AND 10), AND VARIANT
RP THR-464.
RC TISSUE=Thalamus, Thymus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-464.
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-545.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ALTERNATIVE SPLICING.
RX PubMed=10607901; DOI=10.1016/s0378-1119(99)00465-5;
RA Rong Zeng W., Soucie E., Sung Moon N., Martin-Soudant N., Berube G.,
RA Leduy L., Nepveu A.;
RT "Exon/intron structure and alternative transcripts of the CUTL1 gene.";
RL Gene 241:75-85(2000).
RN [8]
RP SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, SUBUNIT, AND MUTAGENESIS OF
RP TYR-624 AND HIS-629.
RX PubMed=12429822; DOI=10.1091/mbc.e02-06-0349;
RA Gillingham A.K., Pfeifer A.C., Munro S.;
RT "CASP, the alternatively spliced product of the gene encoding the CCAAT-
RT displacement protein transcription factor, is a Golgi membrane protein
RT related to giantin.";
RL Mol. Biol. Cell 13:3761-3774(2002).
RN [9]
RP FUNCTION, AND INTERACTION WITH GOLGA5.
RX PubMed=15718469; DOI=10.1126/science.1108061;
RA Malsam J., Satoh A., Pelletier L., Warren G.;
RT "Golgin tethers define subpopulations of COPI vesicles.";
RL Science 307:1095-1098(2005).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [14]
RP VARIANTS [LARGE SCALE ANALYSIS] GLY-490 AND CYS-609.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in intra-Golgi retrograde transport.
CC {ECO:0000269|PubMed:15718469}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with GOLGA5.
CC {ECO:0000269|PubMed:12429822, ECO:0000269|PubMed:15718469}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:12429822}; Single-pass type IV membrane protein
CC {ECO:0000269|PubMed:12429822}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=11;
CC Comment=Additional isoforms seem to exist.;
CC Name=4; Synonyms=CASP;
CC IsoId=Q13948-1; Sequence=Displayed;
CC Name=11;
CC IsoId=P39880-9; Sequence=External;
CC Name=1;
CC IsoId=P39880-1; Sequence=External;
CC Name=2;
CC IsoId=P39880-2; Sequence=External;
CC Name=3;
CC IsoId=P39880-3; Sequence=External;
CC Name=5;
CC IsoId=P39880-4; Sequence=External;
CC Name=6;
CC IsoId=P39880-5; Sequence=External;
CC Name=7;
CC IsoId=P39880-6; Sequence=External;
CC Name=8;
CC IsoId=Q13948-2; Sequence=VSP_040094;
CC Name=9;
CC IsoId=Q13948-9; Sequence=VSP_045593, VSP_040094;
CC Name=10;
CC IsoId=Q13948-10; Sequence=VSP_045927;
CC -!- SIMILARITY: Belongs to the CASP family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/CUX1ID403ch7q22.html";
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DR EMBL; L12579; AAA35654.1; -; mRNA.
DR EMBL; AK125076; BAG54135.1; -; mRNA.
DR EMBL; AK125097; BAG54140.1; -; mRNA.
DR EMBL; AK303151; BAG64254.1; -; mRNA.
DR EMBL; AK222832; BAD96552.1; -; mRNA.
DR EMBL; AC005072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005086; AAP22331.1; -; Genomic_DNA.
DR EMBL; AC005088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005096; AAS07410.1; -; Genomic_DNA.
DR EMBL; AC005103; AAS07388.1; -; Genomic_DNA.
DR EMBL; AC092788; AAS07523.1; -; Genomic_DNA.
DR EMBL; CH471197; EAW50227.1; -; Genomic_DNA.
DR EMBL; BC025422; AAH25422.1; -; mRNA.
DR CCDS; CCDS47672.1; -. [Q13948-2]
DR CCDS; CCDS56500.1; -. [Q13948-10]
DR CCDS; CCDS5720.1; -. [Q13948-1]
DR CCDS; CCDS59071.1; -. [Q13948-9]
DR RefSeq; NP_001189473.1; NM_001202544.2. [Q13948-10]
DR RefSeq; NP_001189474.1; NM_001202545.2.
DR RefSeq; NP_001189475.1; NM_001202546.2. [Q13948-9]
DR RefSeq; NP_001904.2; NM_001913.4. [Q13948-1]
DR RefSeq; NP_852477.1; NM_181500.3. [Q13948-2]
DR AlphaFoldDB; Q13948; -.
DR SMR; Q13948; -.
DR BioGRID; 107903; 188.
DR IntAct; Q13948; 35.
DR MINT; Q13948; -.
DR iPTMnet; Q13948; -.
DR BioMuta; CUX1; -.
DR DMDM; 85681028; -.
DR EPD; Q13948; -.
DR jPOST; Q13948; -.
DR MassIVE; Q13948; -.
DR MaxQB; Q13948; -.
DR PeptideAtlas; Q13948; -.
DR PRIDE; Q13948; -.
DR ProteomicsDB; 32483; -.
DR ProteomicsDB; 59765; -. [Q13948-1]
DR ProteomicsDB; 59766; -. [Q13948-2]
DR Antibodypedia; 48390; 429 antibodies from 35 providers.
DR DNASU; 1523; -.
DR Ensembl; ENST00000292538.9; ENSP00000292538.4; ENSG00000257923.12. [Q13948-1]
DR Ensembl; ENST00000393824.7; ENSP00000377410.3; ENSG00000257923.12. [Q13948-9]
DR Ensembl; ENST00000437600.9; ENSP00000414091.5; ENSG00000257923.12. [Q13948-2]
DR Ensembl; ENST00000547394.6; ENSP00000449371.2; ENSG00000257923.12. [Q13948-10]
DR Ensembl; ENST00000622516.6; ENSP00000484760.2; ENSG00000257923.12. [Q13948-1]
DR GeneID; 1523; -.
DR KEGG; hsa:1523; -.
DR UCSC; uc003uyt.4; human. [Q13948-1]
DR CTD; 1523; -.
DR DisGeNET; 1523; -.
DR GeneCards; CUX1; -.
DR HGNC; HGNC:2557; CUX1.
DR HPA; ENSG00000257923; Low tissue specificity.
DR MalaCards; CUX1; -.
DR MIM; 116896; gene.
DR neXtProt; NX_Q13948; -.
DR OpenTargets; ENSG00000257923; -.
DR PharmGKB; PA162382924; -.
DR VEuPathDB; HostDB:ENSG00000257923; -.
DR GeneTree; ENSGT00940000159751; -.
DR OrthoDB; 181575at2759; -.
DR BioCyc; MetaCyc:ENSG00000170275-MON; -.
DR PathwayCommons; Q13948; -.
DR Reactome; R-HSA-6811438; Intra-Golgi traffic.
DR SignaLink; Q13948; -.
DR BioGRID-ORCS; 1523; 20 hits in 1116 CRISPR screens.
DR ChiTaRS; CUX1; human.
DR GenomeRNAi; 1523; -.
DR Pharos; Q13948; Tbio.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000257923; Expressed in secondary oocyte and 206 other tissues.
DR ExpressionAtlas; Q13948; baseline and differential.
DR Genevisible; Q13948; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0030173; C:integral component of Golgi membrane; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR012955; CASP_C.
DR Pfam; PF08172; CASP_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disulfide bond; Golgi apparatus;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..678
FT /note="Protein CASP"
FT /id="PRO_0000071790"
FT TOPO_DOM 1..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..678
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT COILED 67..450
FT /evidence="ECO:0000255"
FT COILED 502..556
FT /evidence="ECO:0000255"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 22..58
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045593"
FT VAR_SEQ 58..73
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045927"
FT VAR_SEQ 288..289
FT /note="Missing (in isoform 8 and isoform 9)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040094"
FT VARIANT 464
FT /note="A -> T (in dbSNP:rs803064)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.3"
FT /id="VAR_024923"
FT VARIANT 490
FT /note="S -> G (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036285"
FT VARIANT 545
FT /note="I -> V (in dbSNP:rs2230103)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024924"
FT VARIANT 609
FT /note="R -> C (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1287689842)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036286"
FT MUTAGEN 624
FT /note="Y->L: Retained in the endoplasmic reticulum."
FT /evidence="ECO:0000269|PubMed:12429822"
FT MUTAGEN 629
FT /note="H->L: No effect on subcellular location."
FT /evidence="ECO:0000269|PubMed:12429822"
FT CONFLICT 407
FT /note="N -> S (in Ref. 6; AAH25422)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="I -> V (in Ref. 2; BAG64254)"
FT /evidence="ECO:0000305"
FT CONFLICT 525
FT /note="L -> V (in Ref. 2; BAG64254)"
FT /evidence="ECO:0000305"
FT CONFLICT 551
FT /note="I -> V (in Ref. 3; BAD96552)"
FT /evidence="ECO:0000305"
FT CONFLICT 613
FT /note="S -> P (in Ref. 2; BAG54140)"
FT /evidence="ECO:0000305"
FT CONFLICT 657
FT /note="F -> L (in Ref. 1; AAA35654)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 678 AA; 77455 MW; E587F222825EA47E CRC64;
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL
RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH
DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ
NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI
EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK QLEEKLKGQA
DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN RSLQSENAAL RISNSDLSGR
CAELQVRITE AVATATEQRE LIARLEQDLS IIQSIQRPDA EGAAEHRLEK IPEPIKEATA
LFYGPAAPAS GALPEGQVDS LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL
RADNIKLFEK IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW
DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA TFCAKKFADH
LHKFHENDNG AAAGDLWQ
