CASP_MOUSE
ID CASP_MOUSE Reviewed; 678 AA.
AC P70403; Q7TQJ4; Q91WN6;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Protein CASP;
GN Name=Cux1; Synonyms=Cutl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9332351; DOI=10.1016/s0378-1119(97)00243-6;
RA Lievens P.M.-J., Tufarelli C., Donady J.J., Stagg A., Neufeld E.J.;
RT "CASP, a novel, highly conserved alternative-splicing product of the
RT CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and
RT interacts with full-length CDP in vitro.";
RL Gene 197:73-81(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in intra-Golgi retrograde transport.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with GOLGA5 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=CASP;
CC IsoId=P70403-1; Sequence=Displayed;
CC Name=5;
CC IsoId=P53564-1; Sequence=External;
CC Name=2;
CC IsoId=P53564-2; Sequence=External;
CC Name=3;
CC IsoId=P53564-3; Sequence=External;
CC Name=4;
CC IsoId=P53564-4; Sequence=External;
CC Name=6;
CC IsoId=P53564-5; Sequence=External;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:9332351}.
CC -!- SIMILARITY: Belongs to the CASP family. {ECO:0000305}.
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DR EMBL; U68542; AAB08430.1; -; mRNA.
DR EMBL; BC014289; AAH14289.1; -; mRNA.
DR EMBL; BC054370; AAH54370.1; -; mRNA.
DR CCDS; CCDS71685.1; -. [P70403-1]
DR AlphaFoldDB; P70403; -.
DR SMR; P70403; -.
DR iPTMnet; P70403; -.
DR EPD; P70403; -.
DR MaxQB; P70403; -.
DR PaxDb; P70403; -.
DR PeptideAtlas; P70403; -.
DR PRIDE; P70403; -.
DR ProteomicsDB; 279916; -. [P70403-1]
DR MGI; MGI:88568; Cux1.
DR eggNOG; KOG0963; Eukaryota.
DR eggNOG; KOG2252; Eukaryota.
DR ChiTaRS; Cux1; mouse.
DR Proteomes; UP000000589; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; ISO:MGI.
DR GO; GO:0030173; C:integral component of Golgi membrane; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IMP:MGI.
DR GO; GO:0001822; P:kidney development; IGI:MGI.
DR GO; GO:0030324; P:lung development; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR012955; CASP_C.
DR Pfam; PF08172; CASP_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Disulfide bond; Golgi apparatus;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..678
FT /note="Protein CASP"
FT /id="PRO_0000071791"
FT TOPO_DOM 1..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..678
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT COILED 16..40
FT /evidence="ECO:0000255"
FT COILED 67..374
FT /evidence="ECO:0000255"
FT COILED 427..454
FT /evidence="ECO:0000255"
FT COILED 502..556
FT /evidence="ECO:0000255"
FT MOD_RES 586
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13948"
FT CONFLICT 9
FT /note="S -> F (in Ref. 2; AAH14289)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="A -> T (in Ref. 2; AAH14289/AAH54370)"
FT /evidence="ECO:0000305"
FT CONFLICT 288..289
FT /note="Missing (in Ref. 1; AAB08430 and 2; AAH54370)"
FT /evidence="ECO:0000305"
FT CONFLICT 616
FT /note="T -> M (in Ref. 2; AAH54370)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="G -> S (in Ref. 2; AAH54370)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 678 AA; 77269 MW; C04905EE48CC2D37 CRC64;
MAANVGSMSQ YWKRFDLQQL QRELDAAATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL
RKQVAPLLKS FQGEIDALSK RSKEAEAAFL TVYKRLIDVP DPVPALDVGQ QLEIKVQRLH
DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKSQAET IALEKEQKLQ
NDFAEKERKL QETQMSTTSK LEEAEHKLQT LQTALEKTRT ELFDLKTKYD EETTAKADEI
EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLNAKNSTLK QLEEKLKGQA
DYEEVKKELN TLKSMEFAPS EGAGTQDSTK PLEVLLLEKN RSLQSENATL RISNSDLSGR
CAELQIHLTE ATAKAVEQKE LIARLEQDLS TIQSIQRPDA EGASEQGLEK IPEPIKEATA
LFYGPSMSSS GTLPEGQVDS LLSIISSQRE RFRTRNQELE AESRMAQHTI QALQSELDSL
RADNIKLFEK IKFLQSYPGR GIGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLGLSPW
DKATLGMGRL ILSNKTARTI GFFYTLFLHC LVFLVLYKLA WSESVERDCA ATCAKKFADH
LHKFHESDNG AAAGDLWQ
