Y8045_DICDI
ID Y8045_DICDI Reviewed; 337 AA.
AC Q54YW4; C7G002;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 3.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Probable poly [ADP-ribose] polymerase DDB_G0278045;
DE EC=2.4.2.30;
GN ORFNames=DDB_G0278045;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-
CC aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-
CC COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154,
CC ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102;
CC Evidence={ECO:0000305};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-
CC glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-
CC COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540;
CC Evidence={ECO:0000305};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-
CC ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30; Evidence={ECO:0000305};
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DR EMBL; AAFI02000023; EEU04115.1; -; Genomic_DNA.
DR RefSeq; XP_002649167.1; XM_002649121.1.
DR AlphaFoldDB; Q54YW4; -.
DR SMR; Q54YW4; -.
DR STRING; 44689.DDB0304590; -.
DR PaxDb; Q54YW4; -.
DR EnsemblProtists; EEU04115; EEU04115; DDB_G0278045.
DR GeneID; 8621299; -.
DR KEGG; ddi:DDB_G0278045; -.
DR dictyBase; DDB_G0278045; -.
DR eggNOG; ENOG502S6U3; Eukaryota.
DR HOGENOM; CLU_824937_0_0_1; -.
DR InParanoid; Q54YW4; -.
DR OMA; ESNINTW; -.
DR PhylomeDB; Q54YW4; -.
DR PRO; PR:Q54YW4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR Pfam; PF00644; PARP; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
PE 4: Predicted;
KW Glycosyltransferase; NAD; Reference proteome; Transferase.
FT CHAIN 1..337
FT /note="Probable poly [ADP-ribose] polymerase DDB_G0278045"
FT /id="PRO_0000369249"
FT DOMAIN 21..231
FT /note="PARP catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00397"
FT REGION 218..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 39384 MW; 42056911F3AA9A02 CRC64;
MGRVKMSETF SYWIEDNIYP KKWDIIYKQR ENQVFLIKIN KGSSEYIIVS ERFNETMSNS
FEIIKIERIQ NKSLWRNFDE SRKRLNEKYQ VSNLDFLEST LFHGTRANDP KLIFSSKVGF
DIGKSSFGNY GIGLYFALNA SYSNNYSFEE SPTSGCKQMF LCRVLLGNSA PPTQKELKND
STQDSIKGPG GEMFILKSNH TAYPDYLISY RQKVIVNNNT NNNNKNKNKN NNKNNNKNIK
IQNENKNENK IENKNENENQ FDNYGFNTNF SQNLYDKYGL KYPSQEKPKP GFFTPNKELE
YEIFPLLFEK NEKEEELEEL EDYQLALLLS TSSLGSK
