ID   Y809_STRP6              Reviewed;         200 AA.
AC   Q5XCB9; P82568;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Putative NAD(P)H nitroreductase Spy0809;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=M6_Spy0809;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1] {ECO:0000312|EMBL:AAT86944.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 191-199, AND MASS SPECTROMETRY.
RC   STRAIN=JRS4 / Serotype M6 {ECO:0000269|Ref.2};
RA   Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J.,
RA   VanBogelen R.A.;
RT   "Two-dimensional gel electrophoresis map of Streptococcus pyogenes
RT   proteins.";
RL   Submitted (MAY-2000) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
CC   -!- MASS SPECTROMETRY: Mass=22592.04; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000255}.
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DR   EMBL; CP000003; AAT86944.1; -; Genomic_DNA.
DR   RefSeq; WP_011184478.1; NC_006086.1.
DR   AlphaFoldDB; Q5XCB9; -.
DR   SMR; Q5XCB9; -.
DR   EnsemblBacteria; AAT86944; AAT86944; M6_Spy0809.
DR   KEGG; spa:M6_Spy0809; -.
DR   HOGENOM; CLU_070764_4_5_9; -.
DR   OMA; HLQNWRF; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Flavoprotein; FMN; NAD; NADP; Oxidoreductase.
FT   CHAIN           1..200
FT                   /note="Putative NAD(P)H nitroreductase Spy0809"
FT                   /id="PRO_0000259700"
SQ   SEQUENCE   200 AA;  22520 MW;  3FF12C220561827B CRC64;
     MKFLELNKKR HAIKTFNDQP VDYEDLRTAI EIATLAPSAN NIQPWKFVVV QEKKAELAKG
     LPLANKVQVE QAQYVVALFS DTDLALRSRK IARIGVKSLP DDLIGYYMET LPPRFAAFNE
     VQTGEYLAIN AGIVAMNLVL SLTDQKIASN IILGFDKSTT NGILDIDPRF RPELLITVGY
     SDEKPEPSYR LPVDEVIERR